950818-71-0

Basic information

• Product Name: 2-(2-amino-3-methoxyphenyl)-5,5-dimethylhex-3-yn-2-ol
• Synonyms: 2-(2-amino-3-methoxyphenyl)-5,5-dimethylhex-3-yn-2-ol
• CAS NO: 950818-71-0
• Molecular Weight: 247.337
• Mol File: 950818-71-0.mol

Chemical Properties

• CAS DataBase Reference: 2-(2-amino-3-methoxyphenyl)-5,5-dimethylhex-3-yn-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-amino-3-methoxyphenyl)-5,5-dimethylhex-3-yn-2-ol(950818-71-0)
• EPA Substance Registry System: 2-(2-amino-3-methoxyphenyl)-5,5-dimethylhex-3-yn-2-ol(950818-71-0)

Safety Data

• Hazardous Substances Data: 950818-71-0(Hazardous Substances Data)

Upstream product

• 917-92-0 3,3-Dimethylbut-1-yne 
• 42465-54-3 1-(2-amino-3-methoxyphenyl)ethanone 
• 33852-43-6 1-(3-methoxy-2-nitrophenyl)ethanone 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 

Relevant articles and documents

Versatile synthesis of quinoline-3-carboxylic esters and indol-2-acetic esters by palladium-catalyzed carbonylation of 1-(2-aminoaryl)-2-Yn-1-Ols

(Chemical Equation Presented) 1-(2-Aminoaryl)-2-yn-1-ols, easily obtained by the Grignard reaction between 1-(2-aminoaryl)ketones and alkynylmagnesium bromides, were subjected to carbonylative conditions in the presence of the PdI2-KI catalytic

Novel and convenient synthesis of substituted quinolines by copper- or palladium-catalyzed cyclodehydration of 1-(2-aminoaryl)-2-yn-1-ols

(Chemical Equation Presented) A general and convenient synthesis of substituted quinolines by regioselective copper- or palladium-catalyzed 6-endo-dig cyclization-dehydration of 1-(2-aminoaryl)-2-yn-1-ols is reported. The crude substrates were easily obtained by the Grignard reaction between the appropriate alkynylmagnesium bromide and 2-aminoaryl ketones and could be used without further purification for the subsequent cyclization step. Heteroannulation reactions were carried out in MeOH or DME as the solvent at 60 or 100°C in the presence of CuCl2 or PdX2 (in conjunction with 10 equiv of KX, X = Cl, I) as the catalyst to afford the quinoline derivatives in good to excellent isolated yields based on starting 1-(2-aminoaryl)-2-yn-1-ols (66-90%).