95087-12-0Relevant academic research and scientific papers
Synthesis and Hydrolytic Stability of 4-Substituted Pyrazolopyrimidine 2'-Deoxyribofuranosides
Seela, Frank,Steker, Herbert
, p. 2573 - 2576 (2007/10/02)
Phase-transfer glycosylation of 4-chloro-1H-pyrazolopyrimidine (1) with 2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl chloride (2) yielded the N-1 glycosylation product (3) in 42 percent.The protected intermediate (3) was converted into pyrazolopyrimidine 2'-deoxyribofuranosides with amino, oxo, and thioxo substituents at C-4.Kinetic data of proton-catalysed hydrolysis showed that pyrazolopyrimidine 2'-deoxyribofuranosides are more stable at the N-glycosylic bond than are the parent purine nucleosides.
SYNTHESIS OF 2'-DEOXYRIBONUCLEOSIDES OF ALLOPURINOL BY PHASE-TRANSFER GLYCOSYLATION
Seela, F.,Steker, H.
, p. 5017 - 5018 (2007/10/02)
Regioselective glycosylation of 4-methoxy-1H-pyrazolopyrimidine (6b) with the halogenose 7 was achieved by employing phase-transfer techniques.The N-1 glycosylation product 3a was formed in preponderance.It was converted into the allopurinol β-D-2'-deoxyribonucleoside 2.
