95094-67-0Relevant academic research and scientific papers
Highly regioselective 1,3-dipolar cycloaddition of 3′-O-propargyl guanosine with nitrile oxide: An efficient method for the synthesis of guanosine containing isoxazole moiety
Kore, Anilkumar R.,Senthilvelan, Annamalai,Shanmugasundaram, Muthian
, (2020/10/06)
The 1,3-dipolar cycloaddition reaction of 3′-O-propargyl guanosine with various in-situ generated nitrile oxides in the presence of DMF as a solvent is described. It is noteworthy that the reaction is highly regioselective that affords biologically import
Biologically active hydroxymoyl chlorides as antifungal agents
Ismail, Tabasum,Shafi, Syed,Singh, Parvinder Pal,Qazi, Naveed Ahmed,Sawant, Sanghapal D.,Ali, Intzar,Khan, Inshad Ali,Kumar,Qazi, Ghulam Nabi,Alam, M. Sarwar
, p. 740 - 747 (2008/12/20)
Several oximes and oxime ethers have been developed as antimicrobial agents. A series of chlorooximes (hydroximoyl chlorides) have been synthesized and tested for antifungal activity under in-vitro conditions against Candida albicans, Candida parapsilosis, Candida glabrata, Candida krusei, Aspergillus fumigatus, Aspergilhis flaviis and Aspergillus niger. The derived antifungal activity has been compared with the corresponding oximes. The results show that most of the chlorooximes exhibit potent antifungal activity with anti-isomers showing better activity. It is observed that most of the chlorooximes show interesting antifungal activity (MICs ≤ 32 μg/mL) compared to oximes. Compound 3q (2,3-dimethoxy phenyl hydroxymoyl chloride) is the most active compound. This compound is active against all the Candida species (MIC 0.5 μg/mL) as well as filamentous fungi with MIC range of 2-4 μg/mL. This series of compounds are fungicidal in nature as evident from the MFC results.
(Z)-Stereospecific addition of glycosylmercaptans on nitrilium betaines. Synthesis of 1-S-glucopyranosyl arylthiohydroximates
Brochard,Joseph,Viaud,Rollin
, p. 1403 - 1414 (2007/10/02)
With a view to selecting new internal standards for HPLC analysis of glucosinolates, the synthesis of artificial desulfoglucosinolates 5 was carried out.
Stereochemistry of Indole-2-oximes and Synthesis of Isoxazolylindoles
Hiremath, Shivayogi P.,Thakar, Shreeram B.,Purohit, Muralidhar G.
, p. 926 - 929 (2007/10/02)
5-Methylindole-2-carboxaldehydes (1a and 1b) on bromination with NBS yield the corresponding 3-bromo derivatives (2a and 2b) which have been converted into the oximes (3a and 3b).The attempted dehydrobromination of 3a and 3b with ethanolic KOH, K2CO3 in e
