950995-12-7

Upstream product

• 1571822-53-1 2-[4-chloro-3-(trifluoromethyl)phenyl]propanenitrile 
• 22902-82-5 2-(4-chloro-3-(trifluoromethyl)phenyl)acetonitrile 
• 261763-23-9 4-(bromomethyl)-1-chloro-2-(trifluoromethyl)benzene 

Relevant academic research and scientific papers

ANTAGONISTS OF CHEMOKINE RECEPTORS

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.