951006-38-5Relevant academic research and scientific papers
Repurposing human PDE4 inhibitors for neglected tropical diseases. evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of pdeb1 of trypanosoma brucei
Ochiana, Stefan O.,Bland, Nicholas D.,Settimo, Luca,Campbell, Robert K.,Pollastri, Michael P.
, p. 549 - 564 (2015/04/22)
Cyclic nucleotide phosphodiesterases (PDEs) have been identified as important enzyme targets for drug development in both humans and Trypanosoma brucei, the causative agent of human African trypanosomiasis. With this in mind, we recently reported the prof
QUINOLINE DERIVATIVES USEFUL AS PDE4 INHIBITORS
-
Page/Page column 21, (2010/11/28)
There is provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts or solvates thereof. The invention also relates to the use of said compounds, compositions and medicaments, for example as inhibitors of phosp
