95106-90-4

Upstream product

• 616-02-4 citraconic acid anhydride 
• 82792-81-2 1-(3,4,5-trimethoxyphenyl)-5,6-methylenedioxy-1,3-dihydrobenzothiophene-2,2-dioxide 
• 1026470-10-9 5-<1-Acetoxy-1-(3',4',5'-trimethoxyphenyl)methyl>-6-trimethylsilylmethyl-1,3-benzodioxole 
• 98151-83-8 5-Bromo-6-trimethylsilylmethyl-1,3-benzodioxole 
• 120-57-0 piperonal 
• 6642-34-8 6-bromopiperonyl alcohol 
• 82792-83-4 -3,4-methylenedioxybenzyl alcohol 
• 82792-85-6 5,6-methylenedioxy-1-(3,4,5-trimethoxyphenyl)-1,3-dihydrobenzothiophene 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 
• 98151-84-9 5-<1-Hydroxy-1-(3',4',5'-trimethoxyphenyl)methyl>-6-trimethylsilylmethyl-1,3-benzodioxole 
• 98151-82-7 <(3,4-methylenedioxyphenyl)methyl>trimethylsilane 
• 495-76-1 piperonol 
• 2606-51-1 3,4-Methylenedioxybenzyl bromide 

Downstream Products

• 115425-02-0 (5R,6R,7R)-6-Methyl-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6,7-dicarboxylic acid 7-isopropyl ester 
• 97185-04-1 2-Methyl-4-deoxyisopicropodophyllotoxin 
• 115425-03-1 (5S,6S,7S)-7-Hydroxymethyl-6-methyl-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid 
• 97185-03-0 [(5aR,8aS,9S)-8a-Methyl-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-yl]-acetic acid methyl ester 
• 97185-04-1 2-methyldeoxypodophyllotoxin 
• 97185-01-8 11-carbomethoxymethylidene-2-methylisodeoxypicrophyllotoxin 

Relevant academic research and scientific papers

A Practical Synthesis of the Anti-tumour Agent 2-Methyl-4-deoxyisopicropodophyllotoxin and Related Podophyllin Analogues

We describe an efficient, six-stage synthesis of 2-methyl-4-deoxyisopicropodophyllotoxin, which proceeds via a Diels-Alder cycloaddition between 2-methylmaleic anhydride and the orthoquinodimethane generated by treatment of 5-1-acetoxy-1-(3',4',5'-trimet

The synthesis of structural analogues of the Podophyllum lignans: Selective Wittig reactions on 1-aryl-2-methyl-tetrahydronaphthoic acid anhydride

The title anhydride reacts with stabilised phosphorus ylids exclusively at the carbonyl remote from the 1-aryl substituent. These products have been converted into a variety of compounds related in structure to deoxyisopicrophyllotoxin.

The Synthesis of Lignans and Related Structures using Quinodimethanes and Isobenzofurans: Approaches to the Podophyllins

Novel routes to 1-aryl-5,6-dialkoxy-1,3-dihydrobenzothiophene 2,2-dioxides (13) and to the corresponding benzofuran (8) have been developed; these species yield quinodimethanes (12) via thermal extrusion of SO2 and isobenzofurans (5c) in an acid-cat