95109-65-2Relevant academic research and scientific papers
Synthesis and Antifungal Activity of Coumarinimides
Manrao, M. R.,Kohli, Sunita,Kalsi, P. S.,Sharma, R. C.,Jhooty, J. S.
, p. 1130 - 1132 (2007/10/02)
Condensation of 2-hydroxyphenylethylidenebenzylamines (I) with cyanoacetic acid, cyanoacetamide, malononitrile and ethyl cyanoacetate gives coumarinimides, viz. 4-methyl-4-(N-benzylamino)-3,4-dihydrocoumarinimide-3-carboxylic acids (IV), 4-methyl-4-(N-benzylamino)-3,4-dihydrocoumarinimide-3-carboxamides (V), 4-methyl-3-cyanocoumarinimides (VIII) and 4-methylcoumarinimide-3-carboxylic acid ethyl esters (IX), respectively as a result of cyclization due to interaction between 2-hydroxy and nitrile groups of the adducts (II, III) or of addition-elimination products (VI, VII).All the above coumarinimides except VIII show promising antifungal activity in vitro.
