951120-33-5

Basic information

• Product Name: 3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)Methoxy)-2,6-difluorobenzaMide
• Synonyms: 3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)Methoxy)-2,6-difluorobenzaMide;PC190723
• CAS NO: 951120-33-5
• Molecular Formula: C14H8ClF2N3O2S
• Molecular Weight: 355.7470264
• Product Categories: Amines, Aromatics, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 951120-33-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 218 °C
• Boiling Point: 462.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.593±0.06 g/cm3(Predicted)
• PKA: 14.15±0.50(Predicted)
• CAS DataBase Reference: 3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)Methoxy)-2,6-difluorobenzaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)Methoxy)-2,6-difluorobenzaMide(951120-33-5)
• EPA Substance Registry System: 3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)Methoxy)-2,6-difluorobenzaMide(951120-33-5)

Safety Data

• Hazardous Substances Data: 951120-33-5(Hazardous Substances Data)

Usage

Uses

3-[(6-Chlorothiazolo[5,4-b]pyridin-2-yl)methoxy]-2,6-difluorobenzamide is a small molecule cell-cycle inhibitor and has been used as an antibacterial agent. 3-[(6-Chlorothiazolo[5,4-b]pyridin-2-yl)methoxy]-2,6-difluorobenzamide was found to inhibit bacterial cell division protein FtsZ.

Relevant articles and documents

ANTIBACTERIAL AGENTS

Compounds of formula (I) have antibacterial activity wherein R represents hydrogen or 1, 2 or 3 optional substituents; W is =C(R1)- or =N-; R1 is hydrogen or an optional substituent and R2 is hydrogen, methyl, or fluorine; or R1 and R2 taken together are -CH2-, -CH2CH2-, -O-, or, in either orientation, -O- CH2- Or -OCH2CH2-; R3 is a radical of formula -(Alk1)m-(Z)p-(Alk2)n-Q wherein m, p and n are independently 0 or 1, provided that at least one of m, p and n is 1, Z is -O-, -S-, -S(O)-, -S(O2)-, -NH-, -N(CH3)-, -N(CH2CH3)-, -C(=O)-, -O-(C=O)-, -C(=O)-O-, or an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted divalent bicyclic heterocyclic radical having 5 to 10 ring atoms; Alk1 and Alk2 are optionally substituted C1C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radicals, which may optionally terminate with or be interrupted by -O-, -S-, -S(O)-, -S(O2)-, -NH-, -N(CH3)-, or -N(CH2CH3)-; and Q is hydrogen, halogen, nitrile, or hydroxyl or an optionally substituted monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted bicyclic heterocyclic radical having 5 to 10 ring atoms.