951126-24-2Relevant academic research and scientific papers
Synthesis and in vitro evaluation of xylene linked carbamoyl bis-pyridinium monooximes as reactivators of organophosphorus (OP) inhibited electric eel acetylcholinesterase (AChE)
Acharya, Jyotiranjan,Rana, Hemlata,Kaushik
, p. 3926 - 3933 (2011)
A series of carbamoyl bis-pyridinium monooximes linked with xylene linker were synthesized and their in-vitro reactivation potential was evaluated against acetylcholinesterase (AChE) inhibited by organophosphorus inhibitors (OP) such as sarin, DFP and VX
Monooxime bispyridinium reactivators bearing xylene linker synthesis and in vitro evaluation on model of organophosphate-inhibited acetylcholinesterase
Musilek, Kamil,Hambalek, Jan,Holas, Ondrej,Dohnal, Vlastimil,Kuca, Kamil
, p. 362 - 370 (2016/07/06)
Nine novel mono-oxime reactivators bearing xylene linker were synthesized in an effort to improve previously prepared xylene bisoximes and monocarbamoyl-monooximes. The novel compounds were tested in vitro on the model of tabun-, paraoxon-, methylparaoxon
Monooxime-monocarbamoyl bispyridinium xylene-linked reactivators of acetylcholinesterase - synthesis, in vitro and toxicity evaluation, and docking studies
Musilek, Kamil,Holas, Ondrej,Misik, Jan,Pohanka, Miroslav,Novotny, Ladislav,Dohnal, Vlastimil,Opletalova, Veronika,Kuca, Kamil
scheme or table, p. 247 - 254 (2010/12/18)
Acetylcholinesterase (AChE) reactivators are crucial antidotes to organophosphate intoxication. A new series of 26 monooxime-monocarbamoyl xylene-linked bispyridinium compounds was prepared and tested in vitro, along with known reactivators (pralidoxime, HI-6, obidoxime, trimedoxime, methoxime, K107, K108 and K203), on a model of tabun- and paraoxon-, methylparaoxon- and DFP-inhibited human erythrocyte AChE. Although their ability to reactivate tabun-inhibited AChE did not exceed that of the previously known compounds, some newly prepared compounds showed promising reactivation of pesticide-inhibited AChE. The acute toxicity of the 0ovel compounds was also determined. Docking studies using tabun-inhibited AChE were performed for three compounds of interest. The structure-activity relationship (SAR) study confirmed the apparent influence of the xylene linkage and carbamoyl moiety on the reactivation ability and toxicity of the agents.
