951126-25-3

Basic information

• Product Name: 1-(3-bromomethylbenzyl)-4-hydroxyiminomethylpyridinium bromide
• Synonyms: 1-(3-bromomethylbenzyl)-4-hydroxyiminomethylpyridinium bromide
• CAS NO: 951126-25-3
• Molecular Weight: 386.086
• Mol File: 951126-25-3.mol

Chemical Properties

• CAS DataBase Reference: 1-(3-bromomethylbenzyl)-4-hydroxyiminomethylpyridinium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-bromomethylbenzyl)-4-hydroxyiminomethylpyridinium bromide(951126-25-3)
• EPA Substance Registry System: 1-(3-bromomethylbenzyl)-4-hydroxyiminomethylpyridinium bromide(951126-25-3)

Safety Data

• Hazardous Substances Data: 951126-25-3(Hazardous Substances Data)

Upstream product

• 623-24-5 1,4-bis(bromomethyl)benzene 
• 1193-92-6 3-pyridinealdoxime 

Relevant articles and documents

Monooxime bispyridinium reactivators bearing xylene linker synthesis and in vitro evaluation on model of organophosphate-inhibited acetylcholinesterase

Nine novel mono-oxime reactivators bearing xylene linker were synthesized in an effort to improve previously prepared xylene bisoximes and monocarbamoyl-monooximes. The novel compounds were tested in vitro on the model of tabun-, paraoxon-, methylparaoxon

Synthesis and in vitro evaluation of xylene linked carbamoyl bis-pyridinium monooximes as reactivators of organophosphorus (OP) inhibited electric eel acetylcholinesterase (AChE)

A series of carbamoyl bis-pyridinium monooximes linked with xylene linker were synthesized and their in-vitro reactivation potential was evaluated against acetylcholinesterase (AChE) inhibited by organophosphorus inhibitors (OP) such as sarin, DFP and VX

Monooxime-monocarbamoyl bispyridinium xylene-linked reactivators of acetylcholinesterase - synthesis, in vitro and toxicity evaluation, and docking studies

Acetylcholinesterase (AChE) reactivators are crucial antidotes to organophosphate intoxication. A new series of 26 monooxime-monocarbamoyl xylene-linked bispyridinium compounds was prepared and tested in vitro, along with known reactivators (pralidoxime, HI-6, obidoxime, trimedoxime, methoxime, K107, K108 and K203), on a model of tabun- and paraoxon-, methylparaoxon- and DFP-inhibited human erythrocyte AChE. Although their ability to reactivate tabun-inhibited AChE did not exceed that of the previously known compounds, some newly prepared compounds showed promising reactivation of pesticide-inhibited AChE. The acute toxicity of the 0ovel compounds was also determined. Docking studies using tabun-inhibited AChE were performed for three compounds of interest. The structure-activity relationship (SAR) study confirmed the apparent influence of the xylene linkage and carbamoyl moiety on the reactivation ability and toxicity of the agents.