951161-65-2

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 75889-47-3 2,3-dimethoxy-4-methylbenzaldehyde 
• 4463-33-6 1,2-dimethoxy-3-methylbenzene 
• 951161-64-1 (S)-2-[2-(2,3-dimethoxy-4-methyl-phenyl)-propyl]-4,4,5,5-tetramethyl-[1,3,2]-dioxaborolane 
• 951161-58-3 (R)-2-[1-(2,3-dimethoxy-4-methyl-phenyl)-ethyl]-4,4,5,5-tetramethyl-[1,3,2]-dioxaborolane 
• 951161-56-1 2,3-dimethoxy-1-methyl-4-vinylbenzene 
• 951161-59-4 (S)-2-[3-(2,3-dimethoxy-4-methyl-phenyl)-butyl]-4,4,5,5-tetramethyl-[1,3,2]-dioxaborolane 
• 951161-60-7 (E)-((3-bromo-2-methylallyl)oxy)(tert-butyl)dimethylsilane 

Downstream Products

• 951161-66-3 (S,E)-6-(2,3-dimethoxy-4-methyl-phenyl)-2-methyl-hept-2-en-1-ol 
• 951161-61-8 (S,E)-6-(2,3-dimethoxy-4-methylphenyl)-2-methylhept-2-en-1-yl acetate 

Relevant academic research and scientific papers

Enantioselective synthesis of a trans-7,8-dimethoxycalamenene

trans-7,8-Dimethoxy-11,12-dehydrocalamenene, a projected intermediate for the total synthesis of marine serrulatane and amphilectane diterpenes, was efficiently synthesized. Starting from a styrene, asymmetric Rh-catalyzed hydroboration using a novel chiral P.P-bidentate ligand afforded an organoboron intermediate (93% ee) which was directly used for C-C bond formation (double homologation, Suzuki coupling). The 1,4-trans-disubstituted tetralin skeleton was selectively formed by a Friedel-Crafts-type catlonic cyclization under strictly aprotic conditions (Me2AlCl) to suppress a remarkable proton-catalyzed disproportionation via diastereoselective hydride transfer.