951173-25-4Relevant articles and documents
Stereoselective synthesis of all stereoisomers of orthogonally protected cyclobutane-1,2-diamine and some chemoselective transformations
Sans, Marta,Illa, Ona,Ortuno, Rosa M.
supporting information; experimental part, p. 2431 - 2433 (2012/07/13)
The four stereoisomers of protected cyclobutane-1,2-diamine have been prepared in an enantio- and diastereocontrolled manner through stereodivergent synthetic routes starting from a half-ester as a common chiral precursor. Orthogonal protection allows the
Expedient preparation of all isomers of 2-aminocyclobutanecarboxylic acid in enantiomerically pure form
Fernandes, Carlos,Pereira, Elisabeth,Faure, Sophie,Aitken, David J.
supporting information; experimental part, p. 3217 - 3220 (2009/09/26)
A short, convenient, gram scale protocol has been established to allow facile access to all four stereoisomers of 2-ami-nocyclobutanecarboxylic acid, each in enantiomerically pure form (ee >99%). Starting from the readily available cis racemate, the proce
PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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Page/Page column 119, (2009/03/07)
The present application describes modulators of MIP-1 of formula (I) : or stereoisomers or pharmaceutically acceptable salts thereof, wherein m, Q, T, W, Z, R1, R3, R4, R5, R5a and R5b, are as set forth above. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using the modulators are disclosed.