951173-88-9Relevant academic research and scientific papers
A thiourea-oxazoline library with axial chirality: Ligand synthesis and studies of the palladium-catalyzed enantioselective bis(methoxycarbonylation) of terminal olefins
Gao, Ying-Xiang,Chang, Le,Shi, Hang,Liang, Bo,Wongkhan, Kittiya,Chaiyaveij, Duangduan,Batsanov, Andrei S.,Marder, Todd B.,Li, Chuang-Chuang,Yang, Zhen,Huanga, Yong
supporting information; experimental part, p. 1955 - 1966 (2010/11/03)
We report herein the synthesis of novel chiral S,N-heterobidentate thiourea-oxazoline ligands and their application to palladium-catalyzed enantioselective bis(methoxycarbonylation)s of terminal olefins under mild conditions. Copper salts were found to play multiple roles in this reaction. Substituted 2- phenylsuccinates were obtained in >90% yield and up to 84% ee under optimized conditions.
