95119-33-8

Upstream product

• 50-00-0 formaldehyd 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 542-92-7 cyclopenta-1,3-diene 
• 17279-30-0 (S)-(-)-α-methylbenzylamine hydrochloride 

Downstream Products

• 139025-13-1 (-)-(1S,6R,1'S)-5,5-dichloro-3-(1'-phenylethyl)-3-azabicyclo<4.3.0>non-7-en-4-one 
• 139025-20-0 (-)-(1R,5R,6R,9S,1'S)-5,9-dimethyl-3-(1'-phenylethyl)-3-azabicyclo<4.3.0>nonan-4,8-dione 
• 139068-96-5 (-)-(1R,5S,6R,9S,1'S)-5,9-dimethyl-3-(1'-phenylethyl)-3-azabicyclo<4.3.0>nonan-4,8-dione 
• 139025-16-4 (-)-(1S,5R,6R,7R,8S,1'S)-7,8-epoxy-5-methyl-3-(1'-phenylethyl)-3-azabicyclo<4.3.0>nonan-4-one 
• 139068-97-6 (-)-(1S,5S,6R,7R,8S,1'S)-7,8-epoxy-5-methyl-3-(1'-phenylethyl)-3-azabicyclo<4.3.0>nonan-4-one 
• 139025-21-1 (-)-(1R,5R,6R,9S,1'S)-5,9-dimethyl-3-(1'-phenylethyl)spiro<<3>azabicyclo<4.3.0>nonane-8,2''-<1.3>dithiane>-4-one 
• 139025-19-7 (1S,5aR,5bS)-1,2b-Dimethyl-4-((S)-1-phenyl-ethyl)-hexahydro-4-aza-cyclopropa[cd]indene-2,3-dione 
• 139025-18-6 (5aS,5bS)-2b-Methyl-4-((S)-1-phenyl-ethyl)-hexahydro-4-aza-cyclopropa[cd]indene-2,3-dione 
• 139025-22-2 (+)-(1R,5R,6R,9S,1'S)-5,9-dimethyl-3-(1'-phenylethyl)spiro<<3>azabicyclo<4.3.0>nonane-8,2''-<1,3>dithiane> 
• 139025-17-5 (2S,5aS,5bS)-2-Hydroxy-2b-methyl-4-((S)-1-phenyl-ethyl)-octahydro-4-aza-cyclopropa[cd]inden-3-one 
• 139025-15-3 (1S,6R,1'S)-5-methyl-3-(1'-phenylethyl)-3-azabicyclo<4.3.0>non-7-en-4-one 
• 139025-14-2 (-)-(1S,6R,1'S)-3-(1'-phenylethyl)-3-azabicyclo<4.3.0>non-7-en-4-one 
• 116183-67-6 (-)-δ-N-Normethylskytanthine 
• 881844-52-6 (1R,4R,6S,7R)-7-bromo-6-phenyl-2-[(S)-1-phenylethyl]-2-azabicyclo[2.2.1]heptane 

Relevant academic research and scientific papers

MUSCARINIC RECEPTOR ANTAGONISTS

This present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The inve

Synthesis of 6-substituted 7-bomoazabicyclo[2.2.1]heptanes via nucleophilic addition to 3-bromo-1-azoniatricyclo[2.2.1.0]-heptane bromide

We describe herein an efficient method for the preparation of a functionalised bicyclic framework (6-substituted 7-bromo-aza-bicyclo[2.2.1] heptane) through the selective opening of the aziridium 2 with organocuprates in up to 90% yield. These interesting chiral building blocks were then utilised as novel ligands in the rearrangement of epoxides to afford chiral allylic alcohols.

An improved procedure for the synthesis of chiral 2-aza-bicyclo[2.2.1]heptane

Grieco's protocol for the synthesis of 2-aza-bicyclo[2.2.1]heptane is modified and adapted for large scale preparation. The optical purity of the material is readily upgraded by purification through a chiral salt.