951213-75-5Relevant academic research and scientific papers
Synthesis and evaluation of α,β-unsaturated α-aryl-substituted fosmidomycin analogues as DXR inhibitors
Devreux, Vincent,Wiesner, Jochen,Jomaa, Hassan,Van der Eycken, Johan,Van Calenbergh, Serge
, p. 4920 - 4923 (2008/02/11)
Fosmidomycin, which acts through inhibition of 1-deoxy-d-xylulose phosphate reductoisomerase (DXR) in the non-mevalonate pathway, represents a valuable recent addition to the armamentarium against uncomplicated malaria. In this paper, we describe the synt
