95124-32-6Relevant articles and documents
Selective reductive coupling of nitro aliphatic compounds with aldehydes in hydrogen using gold catalyst
Cisneros, Larisha,Serna, Pedro,Corma, Avelino
, p. 1756 - 1763 (2016)
Nitrones were synthesized in good yields directly from nitro aliphatic compounds, aldehydes, and H2 using highly dispersed gold nanoparticles on titania. The high selectivity for nitrone synthesis contrasts with the platinum supported on carbon
Reductive amination of 5-acetoxymethylfurfural over Pt/Al2O3 catalyst in a flow reactor
Nuzhdin, Alexey L.,Simonov, Pavel A.,Bukhtiyarova, Galina A.,Eltsov, Ilia V.,Bukhtiyarov, Valerii I.
, (2020/12/07)
Aminomethylhydroxymethylfuran derivatives are well known for their pharmaceutical activities. In this work, the two-step one-pot procedure for the synthesis of N-substituted 5-(acetoxymethyl)-2-furfuryl amines was proposed, which includes two successive reactions: the condensation of 5-acetoxymethylfurfural (AMF) with primary amines and the reduction of obtained imines with hydrogen over supported metal catalysts in a flow reactor. The comparison of the properties of Au, Pd and Pt catalysts in the hydrogenation of imine obtained by reaction of AMF with aniline showed that Pt-based catalysts (both Pt/Al2O3 and Pt/C) are highly active and provide high selectivity and stability, while Pd and Au nanoparticles supported on γ-alumina and carbon show low selectivity. A wide range of N-substituted 5-(acetoxymethyl)-2-furfuryl amines was synthesized in good to excellent yields using Pt/Al2O3 catalyst and methanol as a solvent.
Method for preparing N-(5-methylfurfuryl)aniline and derivatives from biomass carbohydrate
-
, (2018/07/30)
The invention discloses a method for preparing N-(5-methylfurfuryl)aniline and derivatives from biomass carbohydrate. The method comprises the following steps: sequentially adding biomass carbohydrate, phosphorous acid, distilled water, hydrogen iodide and an organic solvent to a reaction container; stirring at a normal pressure and a temperature of 30-120 DEG C; reacting for 0.2-5 h; separating atwo-phase solvent; successively extracting and washing an organic layer with sodium sulfite, sodium hydroxide and a saturated salt solution for multiple times; collecting an organic phase to be dewatered by anhydrous magnesium sulfate; sequentially adding a multiphase hydrogenation catalyst, the additional solvent, aniline or aniline derivatives; stirring in a hydrogen atmosphere of normal pressure to 2.0 MPa and at a temperature of normal temperature to 100 DEG C; reacting for 0.2-3.0 h; and separating products. The method provided by the invention mainly uses renewable biomass carbohydrateas the raw material, is completed by two steps so as to be simple to operate and avoid loss of materials caused by intermediate steps, is performed under normal pressure and mild conditions without noble metal catalyst so as to reduce production costs, and has low requirements on equipment.
Selective reductive coupling of nitro compounds with aldehydes to nitrones in H2 using carbon-supported and -decorated platinum nanoparticles
Cisneros, Larisha,Serna, Pedro,Corma, Avelino
supporting information, p. 9306 - 9310,5 (2014/10/15)
Nitrones were synthesized in high yields directly from nitro compounds, aldehydes, and H2 using carbon-decorated platinum nanoparticles. The high selectivity for nitrone synthesis contrasts that of common supported metal catalysts and correspon
Cycloaddition of furfurylamines to maleic anhydride and its substituted derivatives
Zaytsev,Mikhailova,Airiyan,Galkina,Golubev,Nikitina,Zubkov,Varlamov
, p. 505 - 513 (2012/10/29)
The regio- and stereoselectivity of the [4+2] cycloaddition of maleic, citraconic, dichloromaleic, and dibromomaleic anhydrides to difurfuryl amines and secondary furfurylamines were studied. N-Furfuryl-, N-phenyl-, and N-benzylhexahydrooxoepoxyisoindole-7-carboxylic acids were synthesized. An approach was developed for obtaining hexahydroepoxyoxoisoindole-7-carboxylic acid unsubstituted at the nitrogen atom. Aromatization of the oxabicycloheptene fragment of the dihaloepoxyiso-indolonecarboxylic acids gave a series of 7-carboxy-2-R-isoindol-1-ones.
Skeletal Wagner-Meerwein rearrangement of perhydro-3a,6;4,5- diepoxyisoindoles
Zubkov, Fedor I.,Zaytsev, Vladimir P.,Nikitina, Eugeniya V.,Khrustalev, Victor N.,Gozun, Sergey V.,Boltukhina, Ekaterina V.,Varlamov, Alexey V.
, p. 9148 - 9163 (2011/12/01)
An investigation of a skeletal Wagner-Meerwein rearrangement of variously substituted or quinoline-annulated 3a,6;4,5-diepoxyisoindol-1-ones is reported. Optimum reaction conditions (Ac2O, BF3·OEt 2, rt) were discovered fo
Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents
Suvire, Fernando D.,Sortino, Maximiliano,Kouznetsov, Vladimir V.,Vargas M, Leonor Y.,Zacchino, Susana A.,Cruz, Uriel Mora,Enriz, Ricardo D.
, p. 1851 - 1862 (2007/10/03)
The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2
Hydrosilylation of (hetero)aromatic aldimines in the presence of a Pd(I) complex
Iovel,Golomba,Fleisher,Popelis,Grinberga,Lukevics
, p. 701 - 714 (2007/10/03)
The reaction of triethylsilane with heterocyclic and aromatic azomethines, catalyzed by the [Pd(allyl)Cl]2 complex, was studied. It was found that the reaction is affected by the nature of the functional groups in the aza and methine parts of the aldimine molecules, which were produced by the condensation of furan, thiophene, and benzene aldehydes with aniline and its derivatives. The reactivity of a series of imines is compared with their electronic and structural characteristics, determined by quantum-chemical methods. The corresponding furan, thiophene, and aromatic amines and also certain silylamines were synthesized.
STUDIES IN THE FURAN SERIES. 22. N-ARYLFURFURYL- AND N-ARYL-5-METHYLFURFURYLAMINES AND THEIR N-ALLYL DERIVATIVES.
Klepo,Jakopcic
, p. 235 - 237 (2007/10/02)
The compounds, where aryl is a meta- or para-substituted chlorophenyl, methoxyphenyl, or methylphenyl group, were prepared by reduction of corresponding azomethines. Their allylation with allyl iodide or allyl bromide yielded tertiary N-arylfurfurylamines
