951407-26-4Relevant academic research and scientific papers
Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (2MD) selectively eliminates bone calcium mobilization activity
Barycki, Rafal,Sicinski, Rafal R.,Plum, Lori A.,Grzywacz, Pawel,Clagett-Dame, Margaret,DeLuca, Hector F.
experimental part, p. 7658 - 7669 (2010/03/03)
The 18-nor (7), 21-nor (8) and 18,21-dinor (9) analogs of (20S)-1α,25-dihydroxy-2-methylene-19-norvitamin D3 (6, 2MD) were prepared by convergent syntheses. The known phosphine oxide 10 was coupled by the Wittig-Horner process with the correspo
2-Methylene-1Alpha,25-Dihydroxy-18,19,21-Trinorvitamin D3 and Uses Thereof
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Page/Page column 9; 13, (2008/06/13)
Compounds of formula I are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biologic
