951443-46-2Relevant academic research and scientific papers
Second-generation sugar-assisted ligation: A method for the synthesis of cysteine-containing glycopeptides
Ficht, Simon,Payne, Richard J.,Brik, Ashraf,Wong, Chi-Huey
, p. 5975 - 5979 (2008/09/16)
(Chemical Equation Presented) Sweet ligations: A second-generation sugar-assisted ligation is described that incorporates a sugar moiety with an ester-linked thiol auxiliary. Efficient auxiliary removal leads to native glycopeptides without the use of protecting groups. Extended glycopeptides also facilitate efficient ligation reactions by this method, therefore making it possible to scan a target sequence until a synthetically viable ligation junction is found.
