951443-47-3

Upstream product

• 951443-01-9 Ac-Leu-Tyr-Arg-Ala-Tyr-S(CH₂)2CONH₂ 
• 951442-95-8 C₃₇H₅₇N₉O₁₆S₂ 

Downstream Products

• 951443-48-4 C₇₀H₁₀₃N₁₇O₂₃S 

Relevant academic research and scientific papers

METHOD OF PREPARING GLYCOPEPTIDES

A method is provided for the synthesis of glycopeptides using a sugar assisted ligation strategy, wherein an N-terminal peptide portion in the form of a thioester is coopled with a C-terminal peptide portion bearing a carbohydrate moiety comprising a thiol group.

Second-generation sugar-assisted ligation: A method for the synthesis of cysteine-containing glycopeptides

(Chemical Equation Presented) Sweet ligations: A second-generation sugar-assisted ligation is described that incorporates a sugar moiety with an ester-linked thiol auxiliary. Efficient auxiliary removal leads to native glycopeptides without the use of protecting groups. Extended glycopeptides also facilitate efficient ligation reactions by this method, therefore making it possible to scan a target sequence until a synthetically viable ligation junction is found.