951523-75-4

Upstream product

• 952934-74-6 N-cyclopentyl-3-nitropyridin-2-amine 
• 1003-03-8 Cyclopentamine 
• 5470-18-8 2-Chloro-3-nitropyridine 

Downstream Products

• 1359973-09-3 2-(3,5-bis(trifluoromethyl)phenyl)-3-cyclopentyl-3H-imidazo[4,5-b]pyridine 
• 1359973-11-7 4-(3-cyclopentyl-3H-imidazo[4,5-b]pyridin-2-yl)-2-fluorobenzonitrile 
• 1359973-12-8 (4-(3-cyclopentyl-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)(pyrrolidin-1-yl)methanone 
• 1359973-13-9 3-(3-cyclopentyl-3H-imidazo[4,5-b]pyridin-2-yl)-N,N-dimethylbenzenamine 
• 1359973-15-1 2-(2-chloro-3-methylphenyl)-3-cyclopentyl-3H-imidazo[4,5-b]pyridine 

Relevant academic research and scientific papers

Palladium-Catalyzed Suzuki Cross-Coupling of 2-Halo-Deazapurines with Potassium Organotrifluoroborate Salts in the Regioselective Synthesis of Imidazo[4,5-b]pyridine Analogues

In this paper, we report the use of potassium organotrifluoroborate salts as nucleophilic organoboron reagents in the Suzuki cross-coupling reactions of 2-halo deazapurines. Regio-isomeric C-2-substituted imidazo[4,5-b]pyridine analogues were synthesized by employing this protocol in good to excellent yields. Whereas aryl and heteroaryl trifluoroborates reacted readily to give the coupled products in high yields, alkyltrifluoroborates were found to be less reactive. The utilization of tetrabutylammonium acetate was found to play a substantial role in enhancing the reaction rates of the cross-coupling process. Also, a comparative study was performed between boronic acids and potassium organotrifluoroborate salts.

Azabenzimidazole Compounds

The present invention is directed to compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined herein.