951657-74-2Relevant academic research and scientific papers
Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum
Hu, Laixing,Arafa, Reem K.,Ismail, Mohamed A.,Patel, Alpa,Munde, Manoj,Wilson, W. David,Wenzler, Tanja,Brun, Reto,Boykin, David W.
experimental part, p. 6651 - 6658 (2009/12/24)
A series of azaterphenyl diamidines has been synthesized and evaluated for in vitro antiprotozoal activity against both Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f.) and in vivo efficacy in the STIB900 acute mouse model for T
Azaterphenyl diamidines as antileishmanial agents
Hu, Laixing,Arafa, Reem K.,Ismail, Mohamed A.,Wenzler, Tanja,Brun, Reto,Munde, Manoj,Wilson, W. David,Nzimiro, Sandra,Samyesudhas, Serene,Werbovetz, Karl A.,Boykin, David W.
, p. 247 - 251 (2008/09/18)
Eighteen diamidino azaterphenyls and analogues were evaluated as anti-leishmanials; nine of the compounds gave IC50 values less than 1 μM, five exhibited values less than 0.40 μM, and two gave values less than 0.10 μM in a Leishmania donovani a
