95166-02-2

Upstream product

• 501-53-1 benzyl chloroformate 
• 3060-50-2 2,2-diphenylglycine 

Downstream Products

• 53941-54-1 [2-(2-Benzyloxycarbonylamino-2,2-diphenyl-acetylamino)-2,2-diphenyl-acetylamino]-diphenyl-acetic acid 
• 153449-39-9 Z-Dph-Val-OMe 
• 153449-37-7 Z-Dph-Ala-OMe 
• 133910-41-5 N-carbobenzoxy-5,5-diphenyl-2-iminohydantoin 
• 133910-40-4 N-carbobenzoxy-2,2-diphenylglycylcyanamide sodium salt 
• 26975-70-2 5,5-diphenyl-2-iminohydantoin 
• 1421284-22-1 C₂₆H₂₅NO₄ 

Relevant academic research and scientific papers

C-C bond-forming reactions via Pd-mediated decarboxylative α-lmino anion generation

α-lmino anions are generated under neutral reaction conditions via a Pd-mediated decarboxylation of allyl diphenylglycinate imines with concomitant formation of a π-allylpalladium species. The resulting delocalized anion can attack the π-allyl-Pd(ll) spec

Zinc promoted rapid and efficient synthesis of Fmoc- and Z-α,α-dialkylamino acids under neutral conditions

The introduction of Nα-9-fluorenylmethyloxycarbonyl (Fmoc) and benzyloxycarbonyl (Z) groups into α,α-dialkylamino acids is described at neutral pH using Fmoc-Cl or Z-Cl as an acylating agent respectively in the presence of activated zing powder. The reaction is simple, fast and clean. It also permits the scale up with high yields. It is completely free from protected oligomer formation, which is a known side-reaction when Schotten-Baumann procedure is followed. All the Fmoc- and Z-amino acids prepared have been fully characterized.

Synthesis and Anticonvulsant Activity of 2-Iminohydantoins

Iminohydantoins selectively substituted at position C-5 and their 1-carbobenzoxy derivatives have been synthesized, and their anticonvulsant activity was evaluated in mice.In general, the more lipophilic 1-carbobenzoxy iminohydantoins were more potent than the unsubstituted counterparts.Evaluation of the individual enantiomers of the chiral iminohydantoins showed that the anticonvulsant activity resided primarily in the S isomers.In this study, (S)-(+)-1-carbobenzoxy-5-isobutyl-2-iminohydantoin (9a) was the most active member.This compound was not nearly as active as phenythoin against electrically induced convulsions, but was also active against pentylenetetrazole-induced seizures, suggesting a broader clinical potential.The closest analogue of phenytoin, viz., 5,5-diphenyl-2-iminohydantoin (1), failed to show any significant activity.Methylation on N-3 or the imino nitrogen of 1 also did not provide a compound with substantial activity. 2-Thiophenytoin was not active against electoshock seizures and showed only a weak activity against pentylenetetrazole.This study suggested that the structure-activity relationship of 2-iminohydantoins was quite different from that of 2-hydantoins.