951677-52-4Relevant academic research and scientific papers
Application of fragment-based lead generation to the discovery of novel, cyclic amidine β-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency
Edwards, Philip D.,Albert, Jeffrey S.,Sylvester, Mark,Aharony, David,Andisik, Donald,Callaghan, Owen,Campbell, James B.,Carr, Robin A.,Chessari, Gianni,Congreve, Miles,Frederickson, Martyn,Folmer, Rutger H. A.,Geschwindner, Stefan,Koether, Gerard,Kolmodin, Karin,Krumrine, Jennifer,Mauger, Russell C.,Murray, Christopher W.,Olsson, Lise-Lotte,Patel, Sahil,Spear, Nate,Tian, Gaochao
, p. 5912 - 5925 (2008/04/12)
Fragment-based lead generation has led to the discovery of a novel series of cyclic amidine-based inhibitors of β-secretase (BACE-1). Initial fragment hits with an isocytosine core having millimolar potency were identified via NMR affinity screening. Stru
2-AMINOPYRIMIDIN-4-ONES AND THEIR USE FOR TREATING OR PREVENTING Aβ-RELATED PATHOLOGIES
-
Page/Page column 27-28, (2008/06/13)
This invention relates to novel compounds having the structural formula (I) below: [Chemical formula should be inserted here. Please see paper copy] and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds prov
