951745-26-9

Upstream product

• 542-05-2 acetonedicarboxylic acid 
• 28957-72-4 N-benzyltropinone 
• 952423-55-1 C₁₇H₂₁NO₃ 
• 1073923-19-9 benzyl 8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxirane]-8-carboxylate 

Downstream Products

• 1159825-50-9 benzyl 3-(hydroxymethyl)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 951745-28-1 3-(1,5-bis(4-methoxyphenyl)-1H-pyrazol-3-yl)-8-azabicyclo[3.2.1]octane 
• 951743-84-3 3-(1,5-Bis(4-methoxyphenyl)-1H-pyrazol-3-yl)-8-(N-hydroxy-N-methylcarbamoyl)-8-azabicyclo[3.2.1]octane 
• 951745-27-0 8-benzyloxycarbonyl-3-(1,5-bis(4-methoxyphenyl)-1H-pyrazol-3-yl)-8-azabicyclo[3.2.1]octane 

Relevant academic research and scientific papers

APOPTOSIS-INDUCED AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.

HYDROXY SUBSTITUTED ISOQUINOLINONE DERIVATIVES

The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.

UREIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

This invention relates to a pharmaceutical comprising, as an active ingredient, a ureide derivative represented by formula: or a pharmaceutically acceptable salt thereof. The ureide derivative or a pharmaceutically acceptable salt thereof according to the present invention is useful for relieving pain and treating or preventing neuropathic pain.