951771-63-4

Upstream product

• 97966-00-2 5-bromo-2,3-dichloropyridine 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 951771-66-7 1-[5-chloro-6-(4-chloro-phenylamino)-pyridin-3-yl]-ethanone 
• 951771-97-4 (3-chloro-5-pent-1-ynyl-pyridin-2-yl)-(4-chloro-phenyl)-amine 
• 1256157-75-1 5-chloro-6-(4-chlorophenylamino)pyridin-3-ylboronic acid 

Relevant academic research and scientific papers

Benzimidazoles as potent and orally active mGlu5 receptor antagonists with an improved pk profile

A focused chemical optimization effort of compound 1 based on metabolite elucidation is described, resulting in 15i, a highly potent and selective mGlu5 receptor antagonist with an improved pharmacokinetic profile compared to 1. Characterization of 15i in

NOVEL BI-ARYL AMINES

The present invention relates to novel bi-aryl amines of formula (I) and to pharmaceutically acceptable prodrugs, salts, solvates, hydrates, and N-oxides thereof and to pharmaceutical compositions comprising them, methods of their use, and methods of their preparation.