951889-19-3Relevant academic research and scientific papers
A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive ADAMTS-5 (aggrecanase-2) inhibitors
Atobe, Masakazu,Maekawara, Naomi,Ishiguro, Noriko,Sogame, Shinya,Suenaga, Yoshihito,Kawanishi, Masashi,Suzuki, Hiroko,Jinno, Norimasa,Tanaka, Eiichi,Miyoshi, Shiro
, p. 2106 - 2110 (2013/04/24)
A series of thiazole bearing thiazolidin-4-one was discovered via high-throughput screening as non-competitive inhibitors of ADAMTS-5. Compound 31 appeared to give the best ADAMTS-5 inhibition and good selectivity over other metalloproteases.
