951922-49-9Relevant academic research and scientific papers
Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents
Evdokimov, Nikolai M.,Van Slambrouck, Severine,Heffeter, Petra,Tu, Lee,Le Calvé, Benjamin,Lamoral-Theys, Delphine,Hooten, Carla J.,Uglinskii, Pavel Y.,Rogelj, Snezna,Kiss, Robert,Steelant, Wim F.A.,Berger, Walter,Yang, Jeremy J.,Bologa, Cristian G.,Kornienko, Alexander,Magedov, Igor V.
, p. 2012 - 2021 (2011)
After the initial discovery of antiproliferative and apoptosis-inducing properties of a camptothecin-inspired pentacycle based on a 1H-indeno[2′, 1′:5,6]dihydropyrido[2,3-d]pyrimidine scaffold, a library of its analogues as well as their oxidized planar c
