951968-56-2Relevant academic research and scientific papers
Intramolecular cyclization of Mannich reaction for synthesis of pyrimido[2,1-b]-1,3,5-tiadiazines
El-Sherief, Hassan A. H.,Hozien, Zeinab A.,El-Mahdy, Ahmed F. M.,Sarhan, Abdelwarth A. O.
experimental part, p. 1294 - 1302 (2011/02/22)
Reaction of 6-aryl-5-cyano-2-mercapto-3,4-dihydropyrimidin-4-ones with formaldehyde and primary amines in suitable solvent via a double Mannich reaction gave the corresponding 8-aryl-7-cyano-3-N-substituted-pyrimido[2,1-b]- 1,3,5-thiadiazin-6-ones rather
