952-12-5

Usage

Fused heterocyclic organic compound

The compound is a fused heterocyclic organic compound, meaning it consists of two or more rings fused together, in this case, a pyridine ring fused to an imidazole ring.

Pyridine ring

The compound contains a pyridine ring, which is a six-membered aromatic ring with one nitrogen atom replacing one carbon atom in a benzene ring.

Imidazole ring

The compound also contains an imidazole ring, which is a five-membered aromatic ring with two nitrogen atoms at positions 1 and 3.

2-(4-methylphenyl)substituent

The compound has a methylphenyl group attached to the imidazo[4,5-b]pyridine ring at the 2 position, indicating the presence of a substituent that affects the chemical properties of the compound.

Potential applications in organic synthesis and pharmaceutical research

The compound has potential applications in organic synthesis and pharmaceutical research due to its unique chemical structure and biological activities.

Biological activities

Imidazo[4,5-b]pyridine derivatives have been studied for their various biological activities, including antiviral, anticancer, and antifungal properties.

Upstream product

• 452-58-4 2,3-Diaminopyridine 
• 99-94-5 p-Toluic acid 
• 63581-32-8 3-<(4-methylphenyl)methylene>amino-2-pyridineamine 
• 104-87-0 4-methyl-benzaldehyde 

Relevant academic research and scientific papers

Br?nsted acidic reduced graphene oxide as a sustainable carbocatalyst: A selective method for the synthesis of C-2-substituted benzimidazole

Br?nsted acidic reduced graphene acts as an efficient and sustainable carbocatalyst for the selective synthesis of C-2-substituted benzimidazoles under ambient conditions. A massive influx of sulphonic acid group on reduced graphene oxide surface gives graphene sulfonic acid (G-SO3H), which acts as a Br?nsted acidic catalyst for the synthesis of a series of benzimidazoles under mild conditions. The present methodology is a revamp of the benzimidazole synthesis with broad functional group tolerance in shorter time. G-SO3H provides an operationally simple, metal-free condition and is amenable to gram-scale production. Pyridine adsorption studies prove the catalytically responsible Br?nsted acidity of the catalyst. The catalyst is highly stable for several cycles without any loss of activity, which is evidenced by the FT-IR, PXRD and TEM characterization of the reused catalyst.

Eco-friendly and facile synthesis of 2-substituted-1H-imidazo[4,5-b]pyridine in aqueous medium by air oxidation

We report a new environmentally-benign, convenient, and facile methodology for the synthesis of 2-substituted-1H-imidazo[4,5-b]pyridine. The reaction of 2,3-diaminopyridine with substituted aryl aldehydes in water under thermal conditions without the use

Unambiguous structural assignment of monoanils obtained from 2,3-pyridinediamines

The reaction of 2,3-pyridinediamine la and its 5-bromo analogue lb independently with aromatic aldehydes results in the formation of 2-amino-and 5-bromo-2-amino-3-arylideneaminopyridines (2a and 2b) respectively. The structure of 2 has been confirmed by single crystal X-ray analysis, thereby ruling out the alternate structure for these compounds.

Structure and reactions of monoanils obtained from 2,3-pyridinediamines

The reaction of 2,3-pyridinediamines 1 with aromatic aldehydes results in the formation of 2-amino-3-arylideneaminopyridines 2 respectively. Dehydrogenative cyclisation of 2 with different reagents give 2-aryl-1H-imidazo[4,5-b]pyridines 4. Reactions of 2 with different reagents have been described.