952-14-7

Usage

Heterocyclic organic compound

1H-Imidazo[4,5-b]pyridine, 2-(4-fluorophenyl)- contains both imidazole and pyridine rings, which are heterocyclic, meaning they contain atoms other than carbon in the ring structure.

2-(4-fluorophenyl)substitution

This indicates that a fluorine atom is attached to the phenyl group at the 2 position, which can affect the compound's chemical properties and interactions.

Selective serotonin receptor antagonist

1H-Imidazo[4,5-b]pyridine, 2-(4-fluorophenyl)- is known to selectively bind to and block certain serotonin receptors, which can be useful in the development of drugs targeting neurological disorders and mental health conditions.

Potential in medicinal chemistry

The structure and properties of 1H-Imidazo[4,5-b]pyridine, 2-(4-fluorophenyl)- make it a valuable tool for exploring interactions with serotonin receptors and developing novel therapeutic agents.

Upstream product

• 452-58-4 2,3-Diaminopyridine 
• 459-57-4 4-fluorobenzaldehyde 
• 1428156-38-0 2-(4-fluorophenyl)-3-((2-methoxyethoxy)methyl)-3H-imidazo[4,5-b]pyridine 
• 1428156-21-1 3-((2-methoxyethoxy)methyl)-3H-imidazo[4,5-b]pyridine 
• 273-21-2 imidazo[4,5-b]pyridine 

Relevant academic research and scientific papers

Synthesis, NMR, X-ray crystallography and DFT studies of some regioisomers possessing imidazole heterocycles

Imidazole-containing heterocycles: Imidazopyridines, imidazopyrimidines can exist in several tautomeric forms. Their regioselectivities were determined for N-alkylations with 4-chlorobenzyl bromide under basic conditions (K2CO3) in DMF. We observed that, regioisomers were mainly formed as a mixture in this reaction and N-benzylation occurs at a higher ratio on six membered heterocycles. Their structural assignments were made with the use of two-dimensional 1H–1H NOE (Nuclear Overhauser Effect Spectroscopy, NOESY) and 1H-15N HMBC (Heteronuclear Multiple Bond Correlation) spectra. Further confirmation of the structure of 2c and 3c were obtained from X-ray crystallography. Experimental data was confirmed by Density Functional Theory (DFT) studies as well.

Highly efficient, mild, one pot synthesis of 2-substituted benzimidazoles, benzothiazoles and pyridoimidazoles promoted by N-iodosuccinimide

A common and highly efficient metal-free route for the synthesis of 2-substituted benzimidazoles, benzothiazoles and pyridoimidazoles from suitable 1,2-difunctionalised aromatic compounds and various aromatic and aliphatic aldehydes and ferrocenecarboxaldehyde was developed using N-iodosuccinimide as the oxidizing agent. The methodology involved very short reaction time, mild reaction procedure and easy work-up as well as excellent yields of the products.

Regioselective C2-arylation of imidazo[4,5-b]pyridines

We show that N3-MEM-protected imidazo[4,5-b]pyridines undergo efficient C2-functionalisation via direct C-H arylation. Twenty-two substituted imidazo[4,5-b]pyridines are prepared and iterative, selective elaboration of functionalised imidazo[4,5-b]pyridin

Eco-friendly and facile synthesis of 2-substituted-1H-imidazo[4,5-b]pyridine in aqueous medium by air oxidation

We report a new environmentally-benign, convenient, and facile methodology for the synthesis of 2-substituted-1H-imidazo[4,5-b]pyridine. The reaction of 2,3-diaminopyridine with substituted aryl aldehydes in water under thermal conditions without the use

PREPARATION OF 2-ARYL-SUBSTITUTED IMIDAZOPYRIDINES AND IMIDAZOPYRIDINES

It is proposed that sulfur be used as the oxidizing agent in the synthesis of 2-arylimidazopyridines from o-diaminopyridines and aromatic (heteroaromatic) aldehydes.Benzyl alcohols and benzylpyridinium salts can be used in place of aldehydes. 2-Phenylimid