952-54-5 Usage
Uses
Used in Pharmaceutical Industry:
Morinamide is used as an anti-tuberculosis agent for its ability to inhibit the growth of Mycobacterium tuberculosis, the causative agent of tuberculosis. It is particularly effective in treating drug-resistant tuberculosis strains, offering an alternative treatment option for patients with limited therapeutic choices.
Additionally, morinamide may be used in combination with other anti-tuberculosis drugs to enhance the overall efficacy of treatment and improve patient outcomes. Its development and application in the pharmaceutical industry contribute to the ongoing efforts to combat tuberculosis and reduce its global impact.
Originator
Morinamide,Bracco Industria Chimica
S.p.A.
Manufacturing Process
98.5 parts by weight 2-pyrazinecarboxamide was mixed with 260 parts by
volume of diethylamine. 91 parts by weight of 37% formaldehyde was added
to above mixture by stirring for 30 minutes. The reaction mixture was
spontaneously heated to 50°C. Then it heated to reflux for 5 hours on water
bath. After that it was distilled to dryness at temperature between 40°-50°C.
The residue was dissolved with about 200 parts by volume of ligroin (B.P.
60°C) by heating. The solution was filtered hot for removing the not reacted
2-pyrazinecarboxamide. Then it was cooled to -10°C and desired N-
(diethylaminomethyl)-pyrazinecarboxylic acid amide discharged. It was filtered
off and recrystallized from light petrol ester. Yield about 90%, MP: 47°-50°C.500 parts by weight of N-(diethylaminomethyl)pyrazinecarboxylic acid amide
and 2500 parts by volume of was mixed and heated by stirring to temperature
140°-150°C. At 60°-100°C a distillation begun and ended at 127°C (a boiling
point of morpholine). The distillate consisted from diethylamine and
morpholine. After 30-60 minutes the mixture was cooled to 50°C and distilled
in vacuum to dryness. The residue was recrystallized from 400 parts by
volume of benzene to give N-(morpholinomethyl)pyrazinecarboxamide, yield
92%, MP: 114°-117°C.
Check Digit Verification of cas no
The CAS Registry Mumber 952-54-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,5 and 2 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 952-54:
(5*9)+(4*5)+(3*2)+(2*5)+(1*4)=85
85 % 10 = 5
So 952-54-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N4O2/c15-10(9-7-11-1-2-12-9)13-8-14-3-5-16-6-4-14/h1-2,7H,3-6,8H2,(H,13,15)
