95201-27-7

Upstream product

• 6117-91-5 (E/Z)-2-buten-1-ol 
• 50468-21-8 (2S,3S)-2,3-epoxy-1-butanol 
• 76-83-5 trityl chloride 
• 141561-60-6 ((E)-But-2-enyl)-trityl-ether 
• 141561-60-6 Crotyltritylaether 

Downstream Products

• 132150-03-9 (2R,3S)-6-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-1-trityloxy-non-4-yn-2-ol 
• 116103-33-4 (E)-(2S,3R)-4-Ethyl-3-trityloxymethyl-hex-4-en-2-ol 
• 116103-32-3 (E)-(2R,3S)-4-Ethyl-3-methyl-1-trityloxy-hex-4-en-2-ol 
• 199527-51-0 C₂₄H₂₃⁽²⁾H₃O₂ 
• 199527-52-1 C₂₄H₂₂⁽²⁾H₃N₃O 
• 690627-46-4 (2R,3S)-2-benzyloxy-3,4-dimethyl-1-triphenylmethyloxypentane 
• 690627-44-2 (2R,3S)-3,4-dimethyl-1-triphenylmethyloxy-2-pentanol 
• 436091-70-2 3-[1-(tert-butyl-dimethyl-silanyl)-7-methoxy-1H-indol-4-yl]-1-trityloxy-butan-2-ol 
• 155781-68-3 (2R,3S)-3-Methyl-1-trityloxy-pent-4-en-2-ol 
• 155781-67-2 (2R,3R)-3-Methyl-1-trityloxy-pent-4-en-2-ol 
• 95201-28-8 (2R,3R)-3-Methyl-4-trimethylsilanyl-1-trityloxy-pent-4-en-2-ol 
• 213681-94-8 (2RS,3RS)-3-{2-[(S)-2-(t-butyldiphenylsiloxy)-1-methylethyl]-1,3-dithian-2-yl}-1-(triphenylmethoxy)-2-butanol 

Relevant academic research and scientific papers

Asymmetric synthesis of dihydroindanes by convergent alkoxide-directed metallacycle-mediated bond formation

A convergent synthesis of highly substituted and stereodefined dihydroindanes is described from alkoxide-directed Ti-mediated cross-coupling of internal alkynes with substituted 4-hydroxy-1,6-enynes (substrates that derive from 2-directional functionaliza

Room-temperature metallation of 2-substituted 1,3-dithiane derivatives and subsequent coupling with 2,3-disubstituted oxiranes

2-Substituted 1,3-dithiane derivatives, (S)-1(t-butyldiphenylsiloxy)-2- (1,3-dithian-2-yl)propane (9), (S)-1-(t-butyldimethylsiloxy)-2-(1,3-dithian- 2-yl)propane, 1-(t-butyldiphenylsiloxy)-2-(1,3-dithian-2-yl)-2-methylpropane, and 1,2-bis-(t-butyldiphenylsiloxy)-3-(1,3-dithian-2-yl)propane, were subjected to lithiation in THF with n-BuLi at room temperature (r.t.); the resulting anions reacted with 2,3-disubstituted oxirane, trans-2-methyl-3- (triphenylmethoxymethyl)oxirane(22), at r.t., giving the coupling products in satisfactory yield. On the other hand, the lithium salt formed in ether from (S)2-(1,3-dithian-2-yl)-1-(4-methoxybenzyloxy)propane with n-BuLi at r.t. reacted with 22 at r.t. in the presence of hexamethylphosphoric triamide to afford the coupling product in moderate yield. In addition, a mixed organometallic reagent, n-BuLi/Bu2Mg, was found to be an effective metallation reagent for 9 and the resulting anion reacted with 22 to afford the coupling product in good yield.

The preparation of L-(2S,3S)-4,4,4-[2H3] valine

Isotopically labeled amino acids are important for protein structure determination and in biosynthetic studies. We report now on the synthesis of(2S,3S)-4,4,4-[2H3] valine (9) using a short, versatile, enzyme-free procedure. The deut

First Example of Reversal of Normal Stereoselectivity in the Intramolecular Pauson-Khand Reaction

Stereoselectivity favoring exo substituent orientation in the intramolecular Pauson-Khand reaction of 3-methyl-4-hydroxy-1,6-heptenynes to form bicyclooctenones is affected by the relative stereochemistry at C3 and C4.Cycloaddition of one stereoiso

Stereoselective Synthesis of the C-8 to C-15 Moiety of Erythronolide A

Enantiomerically pure ketone 2, corresponding to the C-8, C-15 segment of erythronolide A, has been prepared by a 12-step route with crotyl alcohol as starting material in 5-6percentoveral yield.The synthesis starts with trisylhydrazone 4, which is conver

DIASTEREO- AND ENANTIOSELECTIVE PREPARATION OF β-ALKYLHOMOALLYLIC ALCOHOLS SYNTHESIS OF SERRICORNIN AND CORYNOMYCOLIC ACID

A new and efficient method for the preparation of four possible stereoisomers of β-alkylhomoallylic alcohols 1 has been developed which is based on the diastereoselective addition of nucleophiles to optically active α-alkyl-β-trimethylsilyl-β,γ-unsaturate