95204-44-7Relevant academic research and scientific papers
First Gewald reaction ignited by sodium polysulfide: Greener ultrasound-promoted synthesis of substituted 2-aminothiophenes in the absence of catalyst
Liang, Chengyuan,Lei, Dong,Wang, Xiuzhen,Zhang, Qingqing,Yao, Qizheng
, p. 458 - 463 (2013/10/21)
In this paper, a modified and facile Gewald reaction triggered by sodium polysulfide in the absence of catalytic base was developed. This approach involves a one-pot ultrasound-irritated aqueous reaction between ketones or aldehydes, malononitrile, and sodium polysulfide, which are converted into the corresponding 2-aminothiophene derivatives in moderate to high yields. In comparison with conventional methods, the prominent features of this sonocatalyzed procedure are experimental simplicity, good functional group tolerance, atom efficiency, and the use of water as a green solvent.
A facile and practical one-pot synthesis of multisubstituted 2-aminothiophenes via imidazole-catalyzed Gewald reaction
Huang, Xian-Gui,Liu, Jia,Ren, Jiangmeng,Wang, Tao,Chen, Weidong,Zeng, Bu-Bing
experimental part, p. 6202 - 6205 (2011/09/19)
A simple and efficient procedure was developed for the synthesis of multisubstituted 2-aminothiophene derivatives. In the presence of catalytic amount of imidazole, ketones or aldehydes, dicyanomethane and elemental sulfur were converted into the corresponding 2-aminothiophene derivatives in moderate to high yields in DMF at 60 °C.
