952055-91-3Relevant academic research and scientific papers
The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2
D'Alessandro, Pier L.,Corti, Corrado,Roth, Adelheid,Ugolini, Annarosa,Sava, Anna,Montanari, Dino,Bianchi, Federica,Garland, Stephen L.,Powney, Ben,Koppe, Emma L.,Rocheville, Magalie,Osborne, Greg,Perez, Paloma,de la Fuente, Jesus,De Los Frailes, Maite,Smith, Paul W.,Branch, Clive,Nash, David,Watson, Stephen P.
scheme or table, p. 759 - 762 (2010/05/19)
The optimisation of an HTS hit series (1) leading to the identification of structurally novel, selective, orally bioavailable mGluR2 positive modulators GSK1331258 and GSK1331268 is described. Structure-activity relationships, attenuation of dopaminergic
Bicyclic Benzimidazole Compounds and Their Use as Metabotropic Glutamate Receptor Potentiators
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Page/Page column 32; 41, (2009/08/14)
Compounds of Formula I: wherein A, B, D, L, R1, R2, R3, R4, m, and n are as defined for Formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
