952093-47-9Relevant academic research and scientific papers
Synthesis, characterization, and in vitro evaluation of a potentially selective anticancer, mixed-metal [ruthenium(III)-platinum(II)] trinuclear complex
Herman, Amnon,Tanski, Joseph M.,Tibbetts, Michael F.,Anderson, Craig M.
, p. 274 - 280 (2008)
A new type of mixed-metal trinuclear complex containing platinum(II) and ruthenium(III) fragments that resemble both cisplatin and NAMI-A has been synthesized and characterized by IR, 1H NMR, elemental analysis, and X-ray crystallography. The water-soluble compound Na2{trans,cis, trans-[RuIIICl4(DMSO-S)(μ-pyz)]2Pt IICl2} (AH-197, pyz = pyrazine) was assessed for its effects on DNA mobility and toxicity against human cancer cell lines. When compared to cisplatin and KP-1019 (which structurally resembles NAMI-A), IC 50 results showed that AH-197 had an intermediate toxicity. When this data was coupled with a subsequent COMPARE evaluation (standard COMPARE queries resulted in insignificant correlation coefficients (a correlation coefficient of 0.19 when compared to cisplatin and 0.25 when compared to KP1019 indicating that AH-197 has a unique behavior.
Synthesis and characterization of ionic Ru(III) complexes containing dimethylsulfoxide and dinitrogen heterocyclic ligands
Anderson, Craig M.,Herman, Amnon,Rochon, Fernande D.
, p. 3661 - 3668 (2008/10/09)
Several new Ru(III) DMSO compounds including [PPh4]trans-[Ru(DMSO)2Cl4], [PPh4]trans-[Ru(DMSO)(pyrazine)Cl4] (2), [PPh4]trans-[Ru(DMSO)(4,4′-bipyridine)Cl4] and [PPh4]trans-[Ru(DMSO)(pyrimidine)Cl4] were reported and characterized. The crystal structure of 2 and its Na+ analogue were determined by X-ray diffraction methods. The PPh4+ complex 2 is a discrete ionic compound, while the compound [Na]trans-[Ru(DMSO)(pyrazine)Cl4] · DMSO (3) crystallized with a molecule of DMSO. The environment around the Na atom is a distorted octahedron with short contacts with three chloro ligands, two O atoms from the bonded and unbonded DMSO molecules, and the unbonded N atom of the pyrazine ligand. The Na atoms form bridges between the complexed anions in 3 resulting in the formation of infinite chains or ribbons parallel to the b axis. The chains are held together by van der Waals interactions.
