952116-03-9Relevant academic research and scientific papers
A new,: Substituted palladacycle for ppm level Pd-catalyzed Suzuki-Miyaura cross couplings in water
Takale, Balaram S.,Thakore, Ruchita R.,Handa, Sachin,Gallou, Fabrice,Reilly, John,Lipshutz, Bruce H.
, p. 8825 - 8831 (2019)
A newly engineered palladacycle that contains substituents on the biphenyl rings along with the ligand HandaPhos is especially well-matched to an aqueous micellar medium, enabling valued Suzuki-Miyaura couplings to be run not only in water under mild conditions, but at 300 ppm of Pd catalyst. This general methodology has been applied to several targets in the pharmaceutical area. Multiple recyclings of the aqueous reaction mixture involving both the same as well as different coupling partners is demonstrated. Low temperature microscopy (cryo-TEM) indicates the nature and size of the particles acting as nanoreactors. Importantly, given the low loadings of Pd invested per reaction, ICP-MS analyses of residual palladium in the products shows levels to be expected that are well within FDA allowable limits.
Spectral properties and charge-transfer complexes of the cyclophanes having the pyrene moiety
Tsuge, Akihiko,Ikeura, Yukihiro,Moriguchi, Tetsuji,Yamaji, Minoru
, p. 1016 - 1017 (2008/02/10)
Novel cyclophanes having the pyrene moiety have been synthesized. The fluorescence and phosphorescence properties have been examined in terms of their structure. It has been found out that their charge-transfer complexes reflect the transannular π-π inter
