952138-13-5

Usage

Uses

Used in Pharmaceutical Industry:
1,6-Naphthyridine, 4,7-dichlorois used as a building block for the synthesis of various pharmaceutical products. Its unique structure allows for the development of new medicinal compounds with potential therapeutic applications.
Used in Agrochemical Industry:
1,6-Naphthyridine, 4,7-dichlorois also used as a building block in the synthesis of agrochemical products. Its unique properties can contribute to the development of new agrochemicals with improved efficacy and selectivity.
Used in Medicinal Chemistry Research:
1,6-Naphthyridine, 4,7-dichlorois utilized in medicinal chemistry research for the exploration of its potential biological activities. Its unique structure and properties make it a valuable compound for studying its interactions with biological targets and its potential as a therapeutic agent.

Upstream product

• 863785-66-4 5,7-dichloro-1H-1,6-naphthyridin-4-one 
• 2587-02-2 2,6-dichloro-[4]pyridylamine 
• 863785-65-3 5-[[(2,6-dichloropyridin-4-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 952138-12-4 7-chloro-1H-1,6-naphthyridin-4-one 

Downstream Products

• 952138-14-6 tert-butyl 2-[4-(7-chloro-1,6-naphthyridin-4-yloxy)-2-methoxyphenyl]acetate 
• 952138-11-3 2-[4-(7-chloro-1,6-naphthyridin-4-yloxy)-2-methoxyphenyl]acetic acid 

Relevant academic research and scientific papers

PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF

The present invention discloses a pyrido-azacyclic compound represented by formula I, an isomer thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, a preparation process thereof and a composition comprising the compound, and a use thereof as a multi-target protein kinase inhibitor in the preparation of a medicament for the treatment of diseases that are associated with protein kinase, especially c-Met, such as cancer and the like. The compound represented by formula I has potent inhibitory activity on tumor cells with overexpression of c-Met kinase, can effectively target c-Met-mediated signaling pathway, and can be used in the treatment of diseases such as cancer and the like that is caused by the overexpression of c-Met kinase.

NAPHTHYRIDINE DERIVATIVES AS ANTI-CANCER AGENTS

The invention concerns naphthyridine derivatives of Formula (I): or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, G1, G2, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders or disease states associated with angiogenesis and/or vascular permeability.