952151-39-2

Usage

Uses

Used in Pharmaceutical and Agrochemical Production:
Tert-butyl 1,2,5-oxadiazepane-2-carboxylate is utilized as a building block in organic synthesis, particularly for the development of pharmaceuticals and agrochemicals. Its unique structure and properties allow for the creation of various biologically active compounds with potential therapeutic and pesticidal effects.
Used in Medicinal Chemistry:
Due to its potential biological activities, tert-butyl 1,2,5-oxadiazepane-2-carboxylate is employed in medicinal chemistry for the design and synthesis of new drugs. Its antimicrobial, antifungal, and antiviral properties make it a valuable component in the development of treatments for various infectious diseases.
Used in Organic Chemistry Reactions:
Tert-butyl 1,2,5-oxadiazepane-2-carboxylate serves as a protecting group for amines in organic chemistry reactions. This function is crucial for preventing unwanted side reactions and ensuring the successful synthesis of desired compounds, thereby enhancing the efficiency and selectivity of organic synthesis processes.

Upstream product

• 952151-38-1 5-benzyl-2-(tert-butyl) 1,2,5-oxadiazepane-2,5-dicarboxylate 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 

Downstream Products

• 952151-41-6 5-(2,6-difluoro-4-nitrophenyl)[1,2,5]oxadiazepane-2-carboxylic acid tert-butyl ester 
• 1138150-66-9 C₁₅H₂₁N₃O₅ 
• 952151-47-2 C₂₁H₂₆F₄N₄O₆ 
• 952151-46-1 C₂₁H₂₈F₂N₄O₆ 
• 1443005-68-2 5(R)-(isoxazol-3-yl-N-(tert-butoxycarbonyl)aminomethyl)-3-(3,5-difluoro-4-(2-(tert-butoxycarbonyl)[1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one 
• 1443005-63-7 5(R)-3-(4-(2-(tert-butoxycarbonyl)[1,2,5]oxadiazepan-5-yl)-3,5-difluorophenyl)-5-(1,2,3-triazol-1-ylmethyl)oxazolidin-2-one 
• 1443005-59-1 O-methyl (S)-N-(3-(4-(1-(tert-butoxycarbonyl)[1,2,5]oxadiazepan-5-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methylthiocarbamate 

Relevant academic research and scientific papers

Heterocyclic Compound

The present invention provide a compound having an orexin receptor antagonistic activity, which is expected to be useful as medicaments such as agents for the prophylaxis or treatment of sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

OXAZOLIDINONE DERIVATIVE HAVING 7-MEMBERED HETERO RING

The present invention provides a novel oxazolidinone derivative of the formula (I): wherein Ring A is (A-1) a 7-membered monocyclic heterocycle containing three N atoms; (A-2) a 7-membered monocyclic heterocycle containing two N atoms and one O atom; or (A-3) a 7-membered monocyclic heterocycle containing two N atoms and one S atom, SO or SO2, wherein said monocyclic heterocycle is optionally substituted, optionally unsaturated and optionally fused with another ring; X1 is a single bond, or a heteroatom-containing group selected from the group consisting of -O-, -S-, -NR2-, -CO-, -CS-, -CONR3-, -NR4CO-, -SO2NR5-, and -NR6SO2-, wherein R2, R3, R4, R5 and R6 are independently hydrogen or lower alkyl, or lower alkylene or lower alkenylene each optionally interrupted by said heteroatom-containing group; Ring B is optionally substituted carbocycle or optionally substituted heterocycle; and R1 is hydrogen, or an organic residue which is able to bind to the 5-position of the oxazolidinone ring in oxazolidinone antimicrobial agents, pharmaceutically acceptable salts and solvates thereof which are useful as an antibacterial agent.

Synthesis and application of [1,2,5]triazepane and [1,2,5]oxadiazepane as versatile structural units for drug discovery

Seven-membered heterocyclic [1,2,5]triazepane and [1,2,5]-oxadiazepane derivatives were synthesized as candidate structures for application in drug discovery in place of conventional piperazine or morpholine moieties, offering multiple sites for modification with functional groups. We first synthesized the Nprotected heterocycles, and then confirmed their utility by synthesizing analogues of the oxazolidinone antibacterial agent linezolid. The analogues exhibited potent in vitro and in vivo antibacterial activity. In particular, compound 10a exhibited good in vivo efficacy when administered intravenously in a murine model of systemic infection with methicillin-resistant Staphylococcus aureus SR3637. These seven-membered heterocycles are expected to be versatile structural units for drug discovery.

NOVEL COMPOUND HAVING HETEROCYCLIC RING

The invention provides a novel oxazolidinone derivative represented by the formula (I): wherein Ring A is optionally substituted or fused and represents (A-1) at least 7-membered monocyclic hetero ring containing at least three N atoms; (A-2) at least 6-membered monocyclic hetero ring containing at least two N atoms and at least one O atom; or (A-3) at least 7-membered monocyclic hetero ring containing at least two N atoms and at least one S atom; X1 is a single bond, -O-, -S-, -NR2-, -CO-, -CS-, - CONR3-, -NR4CO-, -SO2NR5-, and -NR6SO2- (wherein R2 - R6 are independently hydrogen or lower alkyl), or lower alkylene or lower alkenylene in which one of the preceding groups may intervene; Ring B is optionally substituted carbocycle or optionally substituted heterocycle; R1 is hydrogen, or an organic residue which is able to bind to the 5-position of oxazolidinone ring in oxazolidinone antimicrobial agent, and an antibacterial agent containing the same.