952151-39-2

Basic information

• Product Name: tert-butyl 1,2,5-oxadiazepane-2-carboxylate
• Synonyms: tert-butyl 1,2,5-oxadiazepane-2-carboxylate;[1,2,5]Oxadiazepane-2-carboxylic acid tert-butyl ester
• CAS NO: 952151-39-2
• Molecular Formula: C₉H₁₈N₂O₃
• Molecular Weight: 202.26
• Mol File: 952151-39-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 1,2,5-oxadiazepane-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 1,2,5-oxadiazepane-2-carboxylate(952151-39-2)
• EPA Substance Registry System: tert-butyl 1,2,5-oxadiazepane-2-carboxylate(952151-39-2)

Safety Data

• Hazardous Substances Data: 952151-39-2(Hazardous Substances Data)

Usage

General Description

Tert-butyl 1,2,5-oxadiazepane-2-carboxylate is a chemical compound with the molecular formula C10H17N3O3. It is a derivative of oxadiazepane, a heterocyclic compound containing a six-membered ring with two nitrogen atoms and one oxygen atom. Tert-butyl 1,2,5-oxadiazepane-2-carboxylate is commonly used as a building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. tert-butyl 1,2,5-oxadiazepane-2-carboxylate has an important role in medicinal chemistry due to its potential biological activities, such as antimicrobial, antifungal, and antiviral properties. Additionally, it is often employed as a protecting group for amines in organic chemistry reactions. Overall, tert-butyl 1,2,5-oxadiazepane-2-carboxylate is a versatile and valuable chemical with various applications in the field of organic synthesis and pharmaceutical research.

Upstream product

• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 952151-38-1 5-benzyl-2-(tert-butyl) 1,2,5-oxadiazepane-2,5-dicarboxylate 

Downstream Products

• 952151-41-6 5-(2,6-difluoro-4-nitrophenyl)[1,2,5]oxadiazepane-2-carboxylic acid tert-butyl ester 
• 952151-47-2 C₂₁H₂₆F₄N₄O₆ 
• 952151-46-1 C₂₁H₂₈F₂N₄O₆ 
• 1443005-68-2 5(R)-(isoxazol-3-yl-N-(tert-butoxycarbonyl)aminomethyl)-3-(3,5-difluoro-4-(2-(tert-butoxycarbonyl)[1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one 
• 1443005-63-7 5(R)-3-(4-(2-(tert-butoxycarbonyl)[1,2,5]oxadiazepan-5-yl)-3,5-difluorophenyl)-5-(1,2,3-triazol-1-ylmethyl)oxazolidin-2-one 
• 1443005-59-1 O-methyl (S)-N-(3-(4-(1-(tert-butoxycarbonyl)[1,2,5]oxadiazepan-5-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methylthiocarbamate 
• 1138150-66-9 C₁₅H₂₁N₃O₅ 

Relevant articles and documents

Heterocyclic Compound

The present invention provide a compound having an orexin receptor antagonistic activity, which is expected to be useful as medicaments such as agents for the prophylaxis or treatment of sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Synthesis and application of [1,2,5]triazepane and [1,2,5]oxadiazepane as versatile structural units for drug discovery

Seven-membered heterocyclic [1,2,5]triazepane and [1,2,5]-oxadiazepane derivatives were synthesized as candidate structures for application in drug discovery in place of conventional piperazine or morpholine moieties, offering multiple sites for modification with functional groups. We first synthesized the Nprotected heterocycles, and then confirmed their utility by synthesizing analogues of the oxazolidinone antibacterial agent linezolid. The analogues exhibited potent in vitro and in vivo antibacterial activity. In particular, compound 10a exhibited good in vivo efficacy when administered intravenously in a murine model of systemic infection with methicillin-resistant Staphylococcus aureus SR3637. These seven-membered heterocycles are expected to be versatile structural units for drug discovery.