952183-52-7 Usage
Uses
Used in Pharmaceutical Industry:
2-Isopropyl-4-oxopiperidine, N-CBZ protected is used as a key intermediate in the synthesis of various pharmaceutical compounds. The protection of the amine group with a CBZ group allows for selective reactions at other sites on the molecule, facilitating the construction of complex molecular structures. 2-Isopropyl-4-oxopiperidine, N-CBZ protected is particularly useful in the development of drugs targeting the central nervous system, as well as in the synthesis of analgesics, anti-inflammatory agents, and other therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Isopropyl-4-oxopiperidine, N-CBZ protected serves as a valuable building block for the preparation of a wide range of organic molecules. The protected amine group allows for selective functionalization at the carbonyl group or the isopropyl moiety, enabling the synthesis of diverse molecular architectures. 2-Isopropyl-4-oxopiperidine, N-CBZ protected can be used in the preparation of chiral auxiliaries, ligands for asymmetric catalysis, and other specialty chemicals.
Used in Research and Development:
2-Isopropyl-4-oxopiperidine, N-CBZ protected is also utilized in research and development settings, where it can be employed as a model compound for studying the reactivity and selectivity of various synthetic transformations. The protected amine group provides a unique handle for exploring the effects of protecting groups on reaction outcomes and can be used to develop new synthetic methodologies and strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 952183-52-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,2,1,8 and 3 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 952183-52:
(8*9)+(7*5)+(6*2)+(5*1)+(4*8)+(3*3)+(2*5)+(1*2)=177
177 % 10 = 7
So 952183-52-7 is a valid CAS Registry Number.
952183-52-7Relevant academic research and scientific papers
Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and Efficacious γ-Secretase Inhibitors
Ye, Xiaocong M.,Konradi, Andrei W.,Smith, Jenifer,Xu, Ying-Zi,Dressen, Darren,Garofalo, Albert W.,Marugg, Jennifer,Sham, Hing L.,Truong, Anh P.,Jagodzinski, Jacek,Pleiss, Michael,Zhang, Hongbin,Goldbach, Erich,Sauer, John-Michael,Brigham, Elizabeth,Bova, Michael,Basi, Guriqbal S.
scheme or table, p. 2195 - 2199 (2010/07/05)
Discovery of a series of pyrazolopiperidine sulfonamide based γ-secretase inhibitors and its SAR evolution is described. Significant increases in APP potency on the pyrazolopiperidine scaffold over the original N-bicyclic sulfonamide scaffold were achieved and this potency increase translated in an improved in vivo efficacy.
5-(ARYLSULFONYL)-PYRAZOLOPIPERIDINES
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Page/Page column 130, (2010/11/27)
The invention provides N-cyclic sulfonamido compounds of Formula (I) wherein A, B, R1, R1a, R2, R2a, R3 and R3a are as described in the specification. Compounds of Formula (I) are useful in treating or preventing cognitive disorders, such as Alzheimer 's disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I), methods of preparing compounds of formula (I), and methods of treating cognitive disorders, such as Alzheimer's disease.
