952183-69-6

Basic information

• Product Name: 5-Acetyl-2-[(4-fluorophenyl)amino]-4-methyl-1,3-thiazole
• Synonyms: 1-[2-(4-Fluoroanilino)-4-methyl-1,3-thiazol-5-yl]-1-ethanone;5-Acetyl-2-[(4-fluorophenyl)amino]-4-methyl-1,3-thiazole;1-[2-(4-Fluoroanilino)-4-methyl-1,3-thiazol-5-yl]ethan-1-one
• CAS NO: 952183-69-6
• Molecular Formula: C12H11FN2OS
• Molecular Weight: 250.2919432
• Mol File: 952183-69-6.mol

Chemical Properties

• Melting Point: 165-167
• Boiling Point: 381.4±52.0 °C(Predicted)
• Appearance: /
• Density: 1.315±0.06 g/cm3(Predicted)
• PKA: 2.58±0.10(Predicted)
• CAS DataBase Reference: 5-Acetyl-2-[(4-fluorophenyl)amino]-4-methyl-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Acetyl-2-[(4-fluorophenyl)amino]-4-methyl-1,3-thiazole(952183-69-6)
• EPA Substance Registry System: 5-Acetyl-2-[(4-fluorophenyl)amino]-4-methyl-1,3-thiazole(952183-69-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 952183-69-6(Hazardous Substances Data)

Upstream product

• 459-05-2 (4-fluoro-phenyl)-thiourea 
• 123-54-6 acetylacetone 
• 1694-29-7 3-chloropentane-2,4-dione 

Relevant articles and documents

Thiazole fused thiosemicarbazones: Microwave-assisted synthesis, biological evaluation and molecular docking study

In the present study, series of novel compounds (E)-2-(1-(4-methyl-2-(substituted-phenylamino)thiazol-5-yl)ethylidene)hydrazinecarbothio-amide (5a-j) and (E)-N-cyclohexyl-2-(1-(4-methyl-2-(substituted-phenylamino)thiazol-5-yl)ethylidene)hydrazinecarbothio

Visible Light-Mediated Coupling of Thioureas and 1,3-Dicarbonyls: Towards a Leaving Group-Free Synthesis of Aminothiazoles

A synthesis of aminothiazoles from various 1,3-dicarbonyls and thioureas without a leaving group has been developed. The reaction is photocatalyzed by tetraiodofluorescein, an organic dye. Under irradiation with green LEDs, a sulfur radical is generated in situ from thiourea, followed by addition to the enol tautomer, forming the aminothiazole backbone. This novel strategy provides a greener alternative to the traditional leaving group protocols, with excellent atom economy. (Figure presented.).