952193-63-4

Upstream product

• 952193-57-6 (2R,5R)-5-allyl-5-(3-butenyl)-3,6-diethoxy-2,5-dihydro-2-isopropylpyrazine 
• 952193-54-3 (2R,5S)-5-allyl-3,6-diethoxy-2,5-dihydro-2-isopropylpyrazine 
• 952193-60-1 C₁₆H₂₆N₂O₂ 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 952193-64-5 (R)-1-(tert-butoxycarbonylamino)-3-cyclohexene-1-carboxylic acid 
• 952193-67-8 (R)-N-[(1-(tert-butoxycarbonylamino)-cyclohex-3-enyl)carbonyl]-L-phenylalanine methyl ester 

Relevant academic research and scientific papers

Microwave assisted synthesis of spiro-2,5-diketopiperazines

A general and efficient method for the synthesis of spiro-2,5-diketopiperazines (spiro-DKPs) is described. Cyclization of Boc-protected dipeptides containing spiro-amino acids by microwave assisted heating in water furnished the corresponding spiro-DKPs. The spiro-amino acids were prepared by combining stereoselective alkylation reactions using the Sch?llkopf methodology for amino acid construction with Grubbs ring-closing metathesis (RCM) methodology using ruthenium complexes. The RCM reactions and all subsequent transformations to the spiro-DKPs were run with microwave assisted heating, resulting in high yields and short reaction times for all steps.