952193-68-9

Upstream product

• 952193-65-6 (S)-1-(tert-butoxycarbonylamino)-3-cyclohexene-1-carboxylic acid 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 952193-56-5 (2R,5S)-5-allyl-5-(3-butenyl)-3,6-diethoxy-2,5-dihydro-2-isopropylpyrazine 
• 241161-71-7 (2R,5S)-5-(3-butenyl)-3,6-diethoxy-2,5-dihydro-2-isopropylpyrazine 
• 952288-08-3 ethyl (S)-1-(tert-butoxycarbonylamino)-3-cyclohexene-1-carboxylate 
• 952193-61-2 C₁₆H₂₆N₂O₂ 

Relevant academic research and scientific papers

Microwave assisted synthesis of spiro-2,5-diketopiperazines

A general and efficient method for the synthesis of spiro-2,5-diketopiperazines (spiro-DKPs) is described. Cyclization of Boc-protected dipeptides containing spiro-amino acids by microwave assisted heating in water furnished the corresponding spiro-DKPs. The spiro-amino acids were prepared by combining stereoselective alkylation reactions using the Sch?llkopf methodology for amino acid construction with Grubbs ring-closing metathesis (RCM) methodology using ruthenium complexes. The RCM reactions and all subsequent transformations to the spiro-DKPs were run with microwave assisted heating, resulting in high yields and short reaction times for all steps.