952196-30-4

Upstream product

• 52590-27-9 N-methyl-N-(2-cyanomethyl-4,5-dimethoxyphenethyl)acetamide 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 952196-29-1 2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)propionitrile 
• 952196-28-0 cis-2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)acrylonitrile 

Relevant academic research and scientific papers

On the synthesis of protopine alkaloids

(Chemical Equation Presented) For the synthesis of protopine alkaloids, we studied a reaction sequence based on a ring enlargement of indeno[2,1-a][3] benzazepines by a singlet oxygen oxygenation, followed by conversion of an amide carbonyl group of the resultant 10-membered keto-lactam to a methylene group, which is the last step for completion of the synthesis. The key substances, indeno[2,1-a][3]benzazepines, were prepared by Bischler-Napieralski cyclization of alkoxy-substituted 1-(2-bromobenzyl)-3-benzazepin-2-ones. Steric effects of the substituents in this synthesis were examined.