952251-84-2Relevant academic research and scientific papers
Nitroso-ene cyclization enabled access to 1-azaspiro[4.4]nonane and its application in a modular synthesis toward (±)-cephalotaxine
Huang, Sha-Hua,Tian, Xuechao,Mi, Xianwei,Wang, Yan,Hong, Ran
, p. 6656 - 6658 (2015)
In this communication, a nitroso-ene cyclization was devised to rapidly construct 1-azaspiro[4.4]nonane, a key structural motif which was further implemented into the modular synthesis of (±)-cephalotaxine (6). The whole synthesis route to access the key
Convergency and divergency as strategic elements in total synthesis: The total synthesis of (-)-drupacine and the formal total synthesis of (±)-cephalotaxine, (-)-cephalotaxine, and (+)-cephalotaxine
Liu, Qi,Ferreira, Eric M.,Stoltz, Brian M.
, p. 7352 - 7358 (2008/02/12)
(Chemical Equation Presented) A concise route toward the syntheses of (-)-drupacine and (+)- and (-)-cephalotaxine has been developed. The syntheses rely on Pd(II)-catalyzed aerobic oxidative heterocyclization chemistry, which was employed to rapidly cons
