952292-51-2Relevant academic research and scientific papers
Fe(OTf)2-Catalyzed Thia-Michael Addition Reaction: A Green Synthetic Approach to β-Thioethers
Lauzon, Samuel,Li, Mao,Keipour, Hoda,Ollevier, Thierry
supporting information, p. 4536 - 4540 (2018/09/06)
A convenient Fe(OTf)2-catalyzed Michael addition reaction of thiols to α,β-unsaturated carbonyl compounds was developed. The use of a simple procedure (EtOH, room temperature, air atmosphere) allowed to set up effective green catalytic conditions for C–S bond formation. The scope of the reaction was demonstrated using various substituted thiols and original Michael acceptors. The corresponding β-thioethers were obtained in good to excellent yields (up to 99 %). Also, the derivatization into the one-pot thia-Michael addition/oxidation reaction of 3-[3-(phenylthio)butanoyl]oxazolidin-2-one using H2O2 has proven to be efficient.
A bioinspired ZnII/FeIII heterobimetallic catalyst for thia-Michael addition
Lee, Way-Zen,Wang, Tzu-Li,Chang, Hao-Ching,Chen, Yi-Ting,Kuo, Ting-Shen
scheme or table, p. 4106 - 4109 (2012/07/14)
A novel tetranuclear ZnII/FeIII heterobimetallic complex was synthesized, and the complex can efficiently catalyze the Michael addition of thiophenols to α,β-unsaturated enones, even for tertiary carbon-sulfur bond formation.
Chiral squaramide-catalyzed enantioselective conjugate michael addition of various thiols to α,β-unsaturated n-acylated oxazolidin-2-ones
Dai, Le,Yang, Hongjun,Chen, Fener
body text, p. 5071 - 5076 (2011/10/13)
A highly enantioselective sulfa-Michael addition (SMA) of various thiols to α,β-unsaturated N-acylated oxazolidinones has been achieved with a chiral squaramide catalyst under very mild reaction conditions. In addition, the conversion of the β-thio-substi
Catalytic carbon-sulfur bond formation by amphoteric vanadyl triflate: exploring with thia-Michael addition, thioacetalization, and transthioacetalization reactions
Chen, Chien-Tien,Lin, Yow-Dzer,Liu, Cheng-Yuan
supporting information; experimental part, p. 10470 - 10476 (2010/02/28)
A series of thiols have been examined as protic nucleophiles for Michael-type additions to α,β-unsaturated carbonyls as well as double nucleophilic condensations with aldehydes, ketones, and acetals catalyzed by amphoteric, water-tolerant vanadyl triflate under mild and neutral conditions. The newly developed C-S bond formation protocols were carried out smoothly in good to high yields in a highly chemoselective manner.
Asymmetric conjugate addition of thiols to (E)-3-crotonoyloxazolidin-2-one by iron or cobalt/pybox catalyst
Kawatsura, Motoi,Komatsu, Yuji,Yamamoto, Masashi,Hayase, Shuichi,Itoh, Toshiyuki
, p. 3488 - 3493 (2008/09/20)
The enantioselective conjugate addition of thiols to (E)-3-crotonoyloxazolidin-2-one was effectively catalyzed by the Fe(BF4)2·6H2O/(S,S)-ip-pybox catalyst, and the addition product was obtained with up to a 95% ee. Furthe
