95234-45-0Relevant academic research and scientific papers
CHEMICAL PROPERTIES OF YLIDENE DERIVATIVES OF AZINES. 2. THE METHYLATION OF DIHYDROPYRIMIDINYLIDENECYANOACETIC ESTERS AND THEIR ANIONS
Zagulyaeva, O. A.,Grigorkina, O. A.,Mamatyuk, V. I.,Mamaev, V. P.
, p. 1270 - 1275 (1984)
The methylation of dihydropyrimidinylidenecyanoacetic esters by various methylating reagents leads to better yields when anions of ylidene derivatives of pyrimidine are used.The structure of the products of N- and C-methylation formed and their ratio were established with the aid of the IR and UV spectra and by 1H and 13C NMR spectroscopy.The product of C-methylation contains a methyl group at the C(7) atom of the side chain, while the product of N-methylation contains a methyl group at the nitrogen atom of the pyrimidine ring.For 6-ylidene derivatives, N-methylation occurs at the heterocyclic atom distant from the tautomerizing chain.For 2- and 6-ylidene derivatives of pyrimidine, the ratio of the products of N- and C-methylation can be changed by varying the alkylating reagent.
