95237-07-3Relevant academic research and scientific papers
Alternative Sm(II) Species-Mediated Cascade Coupling/Cyclization for the Synthesis of Oxobicyclo[3.1.0]hexane-1-ols
You, Bingxin,Shen, Mengmeng,Xie, Guanqun,Mao, Hui,Lv, Xin,Wang, Xiaoxia
, p. 530 - 533 (2018)
The allylSmBr/HMPA/MsOH system has been found to be an efficient reagent for the "ester-alkene" coupling/cyclization cascade of readily available α-allyloxy esters. Oxobicyclo[3.1.0]hexane-1-ols were thus prepared in good to excellent yields and diastereo
Favourable involvement of α2A-adrenoreceptor antagonism in the I2-imidazoline binding sites-mediated morphine analgesia enhancement
Mammoli, Valerio,Bonifazi, Alessandro,Del Bello, Fabio,Diamanti, Eleonora,Giannella, Mario,Hudson, Alan L.,Mattioli, Laura,Perfumi, Marina,Piergentili, Alessandro,Quaglia, Wilma,Titomanlio, Federica,Pigini, Maria
experimental part, p. 2259 - 2265 (2012/05/05)
Aim of the present study was to obtain novel α2- adrenoreceptor (α2-AR) antagonists, possibly endowed with subtype-selectivity. Therefore, inspired by the non subtype-selective α2-AR antagonist idazoxan, we designed 1,4-di
Enantioselective C-C bond formation by rhodium-catalyzed tandem ylide formation/[2,3]-sigmatropic rearrangement between donor/acceptor carbenoids and allylic alcohols
Li, Zhanjie,Davies, Huw M. L.
supporting information; experimental part, p. 396 - 401 (2010/03/25)
The rhodium-catalyzed reaction of racemic allyl alcohols with methyl phenyldiazoacetate or methyl styryldiazoacetate results in a two-step process, an initial oxonium ylide formation followed by a [2,3]-sigmatropic rearrangement. This process competes favorably with the more conventional O-H insertion chemistry as long as donor/acceptor carbenoids and highly substituted allyl alcohols are used as substrates. When the reactions are catalyzed by Rh2(S-DOSP)4, tertiary R-hydroxycarboxylate derivatives with two adjacent quaternary centers are produced with high enantioselectivity (85-98% ee).
Enantioselective iron-catalysed O-H bond insertions
Zhu, Shou-Fei,Cai, Yan,Mao, Hong-Xiang,Xie, Jian-Hua,Zhou, Qi-Lin
experimental part, p. 546 - 551 (2010/10/04)
The ready availability, low price and environmentally benign character of iron mean that it is an ideal alternative to precious metals in catalysis. Recent growth in the number of iron-catalysed reactions reported reflects an increasing demand for sustainable chemistry. Only a limited number of chiral iron catalysts have been reported and these have, in general, proven less enantioselective than other transition-metal catalysts, thus limiting their appeal. Here, we report that iron complexes of spiro-bisoxazoline ligands are highly efficient catalysts for asymmetric O-H bond insertion reactions. These complexes catalyse insertions into the O-H bond of a wide variety of alcohols and even water, with exceptional enantioselectivities under mild reaction conditions. The selectivities surpass those obtained with other transition-metal catalysts. This study should inspire and encourage the use of iron instead of traditional precious metals in the development of greener catalysts for catalytic asymmetric synthesis.
