95237-08-4

Upstream product

• 20698-91-3 (R)-methyl mandelate 
• 685835-92-1 (1R)-1-O-allyl-1-phenyl-2-O-triphenylmethyl-1,2-ethanediol 
• 80595-15-9 (1R)-1-phenyl-2-O-triphenylmethyl-1,2-ethanediol 
• 16355-00-3 (R)-1-phenyl-1,2-ethanediol 

Downstream Products

• 1370636-88-6 (2S,5R)-(-)-2-(5-phenyl-1,4-dioxan-2-yl)-4,5-dihydro-1H-imidazole 
• 1370636-85-3 (2S,5R)-(-)-(5-phenyl-1,4-dioxan-2-yl)methanol 
• 1370636-86-4 (2R,5R)-(-)-5-phenyl-1,4-dioxane-2-carboxylic acid 
• 1370636-87-5 (2R,5R)-(-)-methyl 5-phenyl-1,4-dioxane-2-carboxylate 
• 685836-01-5 (1R,3'S,4'R)-2-O-(1'',1''-dimethyl-2''-phenyl-ethanesulfonyl)-1-O-(3'-methyl-azetidin-2'-on-4'-yl)-1-phenyl-1,2-ethanediol 
• 685836-02-6 (1R,3'R,4'S)-2-O-(1'',1''-dimethyl-2''-phenyl-ethanesulfonyl)-1-O-(3'-methyl-azetidin-2'-on-4'-yl)-1-phenyl-1,2-ethanediol 
• 685835-97-6 (1R)-2-O-(1'',1''-dimethyl-2''-phenyl-ethanesulfonyl)-1-phenyl-1-O-(Z-prop-1'-en-1'-yl)-1,2-ethanediol 
• 685836-00-4 (1R,3'R,4'S)-2-O-isopropanesulfonyl-1-O-(3'-methyl-azetidin-2'-on-4'-yl)-1-phenyl-1,2-ethanediol 
• 685835-99-8 (1R,3'S,4'R)-2-O-isopropanesulfonyl-1-O-(3'-methyl-azetidin-2'-on-4'-yl)-1-phenyl-1,2-ethanediol 
• 685835-96-5 (1R)-2-O-isopropanesulfonyl-1-O-(Z-prop-1'-en-1'-yl)-1-phenyl-1,2-ethanediol 

Relevant academic research and scientific papers

Favourable involvement of α2A-adrenoreceptor antagonism in the I2-imidazoline binding sites-mediated morphine analgesia enhancement

Aim of the present study was to obtain novel α2- adrenoreceptor (α2-AR) antagonists, possibly endowed with subtype-selectivity. Therefore, inspired by the non subtype-selective α2-AR antagonist idazoxan, we designed 1,4-di

Synthesis, biological, and chiroptical activity of 3-phenyl-clavams

The [2+2]cycloaddition of chlorosulfonyl isocyanate to simple vinyl ethers derived from the 2-O-sulfonylated (R) and (S) 1-phenyl-1,2-ethanediol leads to 4-alkoxy-azetidin-2-ones with a moderate stereoselectivity. The cycloaddition to analogous (Z)-propenyl ethers proceeds stereospecifically with the retention of the olefin configuration. The intramolecular alkylation of β-lactam nitrogen atom furnished all possible stereoisomers of 3-phenyl- and 6-methyl-3-phenyl-clavams. The biological and chiroptical activity of synthesized clavams was investigated. The (3R,5R)-diastereomer 30 showed higher inhibition of bacterial enzymes than other related compounds.