952413-01-3Relevant academic research and scientific papers
Synthesis, resolution, and antiplatelet activity of 3-substituted 1(3H)-isobenzofuranone
Yang, Hua,Hu, Gao-Yun,Chen, Jun,Wang, Yi,Wang, Zhong-Hua
, p. 5210 - 5213 (2008/02/11)
A series of 3-substituted-1(3H)-isobenzofuranone 6a-g and 7a-g were synthesized from phthalic anhydride. The compound 6a-g was resolved. The antiplatelet activities of these compounds were evaluated using in vitro experiment of platelet aggregation. The levels of antiplatelet activity were displayed as following sequence: l-isomer > dl-isomer > d-isomer, respectively. The alkylphthalide is more active than the corresponding alkenephthalide. All these compounds were less active than n-butylphthalide (NBP, 6c) and Aspirin (Asp).
