952428-39-6Relevant articles and documents
Enantioselective [3 + 2]-cycloadditions catalyzed by a protected, multifunctional phosphine-containing α-amino acid
Cowen, Bryan J.,Miller, Scott J.
, p. 10988 - 10989 (2007)
Catalytic asymmetric [3 + 2]-cycloaddition reactions between α-allenic esters and enones are presented. We have found that a simple phosphine-containing protected α-amino acid derivative is capable of promoting such cycloadditions in high yields with significant levels of regioselectivity and enantioselectivity. Furthermore, employing chiral racemic γ-substituted allenoates in the cycloaddition with chalcone substrates results in a "deracemization" reaction furnishing cyclopentenes in high yields with up to 93% ee. Copyright
